The effect of probiotics and Otilonium Bromide on intestinal microorganisms of patients with under diarrhea irritable bowel syndrome
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摘要: [目的]探讨益生菌联合奥替溴铵用在腹泻型肠易激综合征(IBS-D)患者中的应用效果及价值。[方法]将我院治疗的IBS-D患者88例采用随机数字法分为观察组和对照组,对照组给予奥替溴铵治疗,观察组联合益生菌治疗,记录2组效果。[结果]观察组治疗总有效率为93.18%,对照组治疗总有效率为75.00%,组间对比差异有统计学意义(P＜0.05)。观察组治疗后白细胞介素-8(2.06±0.34)ng/L,肿瘤坏死因子-α(32.14±6.11)ng/L;对照组治疗后白细胞介素-8(3.84±0.87)ng/L,肿瘤坏死因子-α(58.36±8.42)ng/L,组间对比差异有统计学意义(P＜0.05)。观察组治疗后乳杆菌属(9.76±0.94)1 gCFU/d,肠球菌属(12.06±1.84)1 gCFU/d,酵母样真菌(3.41±0.19)1 gCFU/d;对照组治疗后乳杆菌属(9.03±0.48)1 gCFU/d,肠球菌属(10.59±1.23)1 gCFU/d,酵母样真菌(4.02±0.57)1 gCFU/d,组间比较差异有统计学意义(P＜0.05)。[结论]益生菌联合奥替溴铵应用在IBS-D患者中可以提升临床疗效,维持肠道微生态平衡,值得在临床上推广应用。Abstract: [Objective]To investigate the effect and application value of probiotics combined with bromide in patients with IBS-D.[Methods]The 88 IBS-D patients treated in our hospital were randomly divided into observation group and control group,control group given bromide treatment and the observation group with probiotic therapy also,record the effect of two groups.[Results]The total efficiency of the observation group is 93.18%,and the treatment of the control group is 75.00%,comparing differences between groups was statistically significant(P<0.05).Observation group after treatment interleukin 8(2.06±0.34)ng/L,tumor necrosis factor alpha(32.14 ±6.11)ng/L;The control group after treatment interleukin 8(3.84±0.87)ng/L,tumor necrosis factor alpha(58.36±8.42)ng/L,comparing differences between groups was statistically significant(P<0.05).Observation group after treatment lactobacillus gcfu(9.76±0.94)1/d,enterococcus gcfu(12.06±1.84)1/d,fungal yeast sample 1 gcfu/d(3.41±0.19);Control group after treatment 1 gcfu lactobacillus genus(9.03±0.48)/d,enterococcus gcfu(10.59±1.23)1/d,sample yeast fungus(4.02±0.57)gcfu/1 d,comparing differences between groups was statistically significant(P<0.05).[Conclusion]The application of probiotics combined with bromide can improve clinical curative effect in patients with IBS-D,maintain intestinal microecological balance,it is worth promoting the application in clinical practice.
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Key words:
- Probiotics /
- Otilonium Bromide /
- Diarrhea type irritable bowel syndrome
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