双歧杆菌三联活菌胶囊联合抗菌治疗对肝硬化自发性细菌性腹膜炎患者肠黏膜屏障功能的影响以及临床疗效分析

陈渠发; 张锡迎; 张宝庭; 陈毅斌; 徐宝琪

doi:10.3969/j.issn.1671-038X.2016.12.16

双歧杆菌三联活菌胶囊联合抗菌治疗对肝硬化自发性细菌性腹膜炎患者肠黏膜屏障功能的影响以及临床疗效分析

- 东莞市第三人民医院消化内科, 广东东莞 523326

详细信息

作者简介:
陈渠发,男,学士,主治医师,研究方向:消化系统感染性疾病

通讯作者: 陈渠发,E-mail:benchen123@163.com

中图分类号: R575.2

收稿日期: 2016-06-30

The effect of Bifico combined antimicrobial therapy on intestinal mucosal barrier function in liver cirrhosis patients with spontaneous bacterial peritonitis and its clinical effect

- Department of Gastroenterology, the Third People's Hospital of Dongguan, Dongguan 523326, China

More Information

Corresponding author: CHEN Qu-fa, E-mail: benchen123@163.com

Received Date: 30 June 2016

摘要

摘要: [目的]观察双歧杆菌三联活菌胶囊联合抗菌治疗对肝硬化自发性细菌性腹膜炎(SBP)患者肠黏膜屏障功能的影响,以及分析其相关的临床疗效。[方法]选取2014年6月~2016年4月我院收治的肝硬化自发性细菌性腹膜炎患者86例,分为对照组和治疗组,每组43例。对照组常规抗菌对症治疗,治疗组在对照基础上加用双歧杆菌三联活菌胶囊(630 mg,3次/d),14 d为一疗程。ELISA法检测腹水中IL-6、TNF-α、IL-10表达,以及血液中DAO和D-乳酸表达,评价临床疗效。[结果]治疗前2组肝硬化自发性细菌性腹膜炎患者腹水IL-6、TNF-α、IL-10表达差异无统计意义(P＞0.05),治疗后治疗组IL-6和TNF-α显著低于对照组(P＜0.01),而IL-10又显著高于对照组(P＜0.01)。治疗前2组肝硬化自发性细菌性腹膜炎患者外周血DAO和D-乳酸差异无统计学意义(P＞0.05),治疗后治疗组DAO和D-乳酸均显著低于对照组(P＜0.01)。治疗组临床治疗有效率为90.70%,显著高于对照组的72.09%(P＜0.05)。[结论]双歧杆菌三联活菌胶囊联合抗菌药物治疗可以调节肝硬化自发性细菌性腹膜炎患者的炎症免疫紊乱状态,保护肠黏膜屏障,有利于损伤肠黏膜功能的恢复,临床疗效显著。
- 肝硬化 /
- 自发性细菌性腹膜炎 /
- 双歧杆菌三联活菌胶囊 /
- 肠黏膜损伤
Abstract: [Objective]To detect the effect of Bifico combined antimicrobial therapy on intestinal mucosal barrier function in liver cirrhosis patients with spontaneous bacterial peritonitis and explore its clinical effect.[Methods]A total of 86 liver cirrhosis patients with spontaneous bacterial peritonitis were enrolled in this study.Patients were randomly divided into control group(n=43)and treatment group(n=43).The control group was given routine antimicrobial treatment.On the base of control group,the treatment group was given Bifico.The two groups were treated with 14 days.The expression of IL-6,TNF-α,IL-10,DAO,and D-Lactate was detected by ELISA analysis.The clinical effect was compared.[Results]Before treatment,The expression of IL-6,TNF-α,IL-10,DAO,and D-Lactate was no significant difference between control and treatment group(P＞0.05).After treatment,IL-6,TNF-α,DAO,and D-Lactate was lower in treatment group than that in control group(P＜0.01).However,IL-10 was higher in treatment group than that in control group(P＜0.01).The clinic effects rate in treatment group was 90.7%,which was better than that of 72.1% in control group(P＜0.05).[Conclusion]Bifico combined antimicrobial therapy inhibited inflammatory response and was conducive to restoring intestinal mucosal injury in liver cirrhosis patients with spontaneous bacterial peritonitis,with worthy of clinical application.
- liver cirrhosis /
- spontaneous bacterial peritonitis /
- Bifico /
- intestinal mucosal injury

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参考文献(9)

[1]	宋媛媛,江宇泳.自发性细菌性腹膜炎诊断与治疗的研究进展[J].临床肝胆病杂志,2016,32(6):1188-1191.
[2]	张兴光,冯志杰.肝硬化自发性细菌性腹膜炎的诊断及治疗进展[J].世界华人消化杂志,2015,23(3):388-395.
[3]	孙雯娟,张波,李大魁,等.益生菌制剂的发展现状与临床应用进展[J].中国医院药学杂志,2015,35(9):850-857.
[4]	中华医学会传染病寄生虫病学会修订.病毒性肝炎防治方案[J].中华传染病学杂志,2000,19(6):241-243.
[5]	丁道献,朱贤勇.双歧杆菌乳杆菌三联活菌片对肝硬化自发性腹膜炎患者肠黏膜屏障功能的保护作用[J].中国微生态学杂志,2014,26(5):549-551.
[6]	KIM J K,CHON C Y,KIM J H,et al.Changes in serum and ascitic monocyte chemotactic protein-1(MCP-1)and IL-10levels in cirrhotic patients with spontaneous bacterial peritonitis[J].J Interferon Cytokine Res,2007,27:227-230.
[7]	THEVENOT T,BUREAU C,OBERTI F,et al.Effect of albumin in cirrhotic patients with infection other than spontaneous bacterial peritonitis.A randomized trial[J].J Hepatol,2015,62:822-830.
[8]	石菡.金双歧对肝硬化自发性腹膜炎肠黏膜屏障功能的影响以及临床疗效研究[J].中国中西医结合消化杂志,2016,24(4):299-301.
[9]	卜仁梅,傅石明.双歧杆菌三联活菌胶囊联合大黄赤芍汤对肝硬化患者内毒素血症及肠黏膜屏障功能的影响[J].中国药房,2016,5:676-678.