Abstract: [Objective]To observe the effect of Qinggan Hewei decoction on 96 primary bile reflux gastritis.[Methods]96 primary bile reflux cases were randomly divided into treatment group(n=62) and control group(n=62).The treatment group patients were treated with Omeprazole,Hydrotalcite and Domperidone.The control group patients were treated with Omeprazole,along with Qinggan Hewei decoction.The degree and frequency of four symptoms abdominal pain,distention,nausea and vomiting,recorded as 0,1,2,3 score,were compared before and after treatment.The total effective rate were calculated and compared.The cover of bile of gastric body was observed under endoscope and compared.[Results]The total effective rate of the two group were 89.6% and 75.0% separately,which have no significant difference.The symptoms of distention,nausea and vomiting of the treatment group were significantly relieved compared with the control group.The cover of bile on gastric body of two groups were different evidently (P＜0.05),which revealed that the effect of inhibiting bile refluxing and neutralizing bile of the treatment group was inferior to the western medicine.[Conclusion]The primary bile gastritis cases tend to be syndrome of incoordination between liver and stomach and heat of gallbladder.Qinggan Hewei decoction is effective and good at relieving syndrome of distention,nausea and vomiting.