Effect of compound matrine injection on the treatment of advanced gastric cancer patients with chemotherapy,immune function,serum tumor markers and toxic and side effects were observed
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摘要: [目的]探讨复方苦参注射液对晚期胃癌化疗患者疗效、免疫功能、血清肿瘤标志物及毒副反应的观察。[方法]98例晚期胃癌患者根据随机数字表法随机分为治疗组49例与对照组49例。对照组仅给予化疗方案,治疗组在化疗基础上联用复方苦参注射液。2组均以14 d为1个疗程,连续观察3个疗程。比较2组患者疗效、免疫功能指标、血清癌胚抗原(CEA)和癌抗原19-9(CA19-9)、生活质量改善情况及药物毒副反应情况。[结果]治疗组总有效率(RR)(57.14%)高于对照组(36.74%)(P＜0.05);治疗组患者CD3+、CD4+、CD4+/CD8+含量治疗后高于对照组(P＜0.05),而CD8+含量治疗后低于对照组(P＜0.05);2组血清CEA和CA19-9水平治疗后均下降(P＜0.05);治疗组血清CEA和CA19-9水平治疗后显著低于对照组(P＜0.05);治疗组生活质量提高明显高于对照组(P＜0.05);治疗组白细胞减少、血小板减少、周围神经毒性、血红蛋白减少及恶心、呕吐发生率显著低于对照组(P＜0.05)。[结论]复方苦参注射液对晚期胃癌化疗患者疗效明显,可提高患者免疫功能,降低血清CEA和CA19-9水平,毒副反应低,具有重要研究意义。Abstract: [Objective]To investigate the effect of compound matrine injection on chemotherapy advanced gastric cancer and observe these patients' immune function, serum tumor markers and adverse reactions. [Methods]98 patients with advanced gastric cancer were randomly and averagely divided into treatment group and control group. Control group only given chemotherapy regimen, the treatment group was treated with compound matrine injection combined with chemotherapy. The two groups were treated with 14 d for 1 courses, 3 courses were observed continuously. The efficacy, immune function, serum levels of cancer embryo antigen(CEA), cancer antigen 19-9(CA19-9), quality of life and adverse drug reactions were compared between the two groups. [Results]RR (57.14%) in treatment group was higher than that in control group (36.74%) (P＜0.05); The content of CD3+、CD4+、CD4+/CD8+ in treatment group was higher than that in control group (P＜0.05), and the content of CD8+ was lower than that of the control group (P＜0.05); Two groups of serum CEA and CA19-9 levels were decreased after treatment (P＜0.05); The level of serum CEA and CA19-9 in the treatment group were significantly lower than those in the control group (P＜0.05); The quality of life in the treatment group was significantly higher than that in the control group (P＜0.05); In the treatment group, the rate of white blood cells reduction thrombocytopenia,peripheral neurotoxicity, hemoglobin decrease, nausea and vomiting were significantly lower than those in the control group (P＜0.05). [Conclusion]Compound matrine injection in the treatment of patients with advanced gastric cancer undergoing chemotherapy has obvious curative effect,including improving the immune function,reducing serum CEA and CA19-9 levels and low toxicity.It has important research significance.
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Key words:
- compound matrine injection /
- advanced gastric cancer /
- chemotherapy /
- efficacy /
- immune function /
- serum tumor markers /
- toxicity
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