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摘要: [目的]探讨乳果糖对非酒精性脂肪性肝炎（NASH）患者肝纤维化指标和血清炎性因子水平的影响。[方法]选取消化科门诊收治的NASH患者78例，随机分为对照组和治疗组。2组患者予以调整饮食，适当体育锻炼及多烯磷脂酰胆碱胶囊456 mg/次，3次/d。治疗组患者在此基础加用乳果糖口服液10 ml，2~3次/d，根据大便频率调整用量使保持大便1~2次/d，连用6周。检测2组患者治疗前后肝功能、肝纤维化指标和血清白介素（IL）-10和IL-18水平的变化。[结果]治疗6周后，2组患者ALT、γ-GT、HA和LN水平较前明显下降（P<0.05、P<0.01），且治疗组下降幅度较对照组更明显（P<0.05）；2组患者血清IL-10水平较前明显上升，IL-18水平较前明显下降（P<0.05、P<0.01），且治疗组改善幅度较对照组更明显。[结论]乳果糖辅助治疗NASH具有良好的疗效，能降低肝功能和肝纤维化指标，促进患者肝功能的恢复，抑制肝纤维组织的增生；并能升高血清IL-10水平，降低血清IL-18水平，从而纠正促炎性因子与抗炎性因子比例失调。
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