小儿开胃增食合剂对小儿厌食症大鼠神经肽Y的影响

王继芳; 吴丽萍; 史正刚; 王英龙; 尚菁

doi:10.3969/j.issn.1671-038X.2016.02.03

小儿开胃增食合剂对小儿厌食症大鼠神经肽Y的影响

- 1. 甘肃中医药大学, 甘肃兰州 730000;
- 2. 甘肃中医药大学附属医院儿科, 甘肃兰州 730020
基金项目:
甘肃省高等学校基金科研项目（No：BH2012-015）

详细信息

作者简介:
王继芳,女,在读硕士研究生,研究方向:小儿脾胃病的防治与研究

通讯作者: 吴丽萍,E-mail:wlplz1@163.com

中图分类号: R272.6

收稿日期: 2015-08-19

The effect of Xiao’erkaiweizengshi Mixture on the content of neural peptide Y inrats with infantile anorexia

- 1. Gansu University of TCM, Lanzhou 730000, China;
- 2. Department of Pediatrics, the Affiliated Hospital of Gansu University of TCM, Lanzhou 730020, China

More Information

Corresponding author: WU Li-ping, E-mail: wlplz1@163.com

Received Date: 19 August 2015

摘要

摘要: [目的]探讨小儿开胃增食合剂对小儿厌食症幼龄大鼠下丘脑和外周血中神经肽Y （neural peptide Y，NPY）的影响。[方法]SD大鼠72只随机分为6组，每组各12只，采用病因模拟法建立小儿厌食症动物模型，分别对幼龄大鼠下丘脑和外周血中NPY含量进行检测。[结果]模型组与空白组、小儿开胃增食合剂中、高剂量组大鼠下丘脑和外周血中NPY含量比较，差异均有统计学意义（P<0.05、P<0.01）；对照组与中、高剂量组下丘脑和外周血中NPY含量比较，差异有统计学意义（P<0.05、P<0.01）；小剂量组与中、高剂量组下丘脑和外周血中NPY含量比较，差异有统计学意义（P<0.05、P<0.01）。[结论]小儿开胃增食合剂可明显改善小儿厌食症幼龄大鼠的食欲，提高下丘脑和外周血中NPY水平，且存在量效关系，这可能是该方治疗小儿厌食症的疗效机理之一。
- 小儿开胃增食合剂 /
- 小儿厌食症 /
- 神经肽Y
Abstract: [Objective] To study the effect of Xiao'erkaiweizengshi Mixture on the content of neural peptide Y(NPY) in hypothalamic and peripheral blood of SD rats with infantile anorexia.[Methods] All 72 rats were randomized into 6 group, 12 rats in each group.The method of etiology simulation was used to set up animal model of infantile anorexia.NPY contents in hypothalamic and peripheral blood were measured respectively.[Results] Compared with model group, there was significant difference in the levels of NPY in hypothalamic and peripheral blood in blank group, high dosage and middle dosage group of Xiao'erkaiweizengshi Mixture(P<0.05, P<0.01).There was significant difference in the levels of NPY in hypothalamic and peripheral blood between control group and high and middle dosage groups of Xiao'erkaiweizengshi Mixture(P<0.05, P<0.01).There was significant difference in the levels of NPY in hypothalamic and peripheral blood between low dosage group and high and middle dosage groups of Xiao'erkaiweizengshi Mixture(P<0.05, P<0.01).[Conclusion] Xiao'erkaiweizengshi Mixture can obviously increase food intake of rats and improve the content of NPY with a dose-dependent manner, which may be one of the important mechanisms in treating children anorexia syndrome.
- Xiao'erkaiweizengshi Mixture /
- infantile anorexia /
- NPY

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