原发性肝癌CT征象与VEGF表达的关系分析

裘加人

doi:10.3969/j.issn.1671-038X.2015.05.09

原发性肝癌CT征象与VEGF表达的关系分析

裘加人^,

- 浙江省临海市第二人民医院放射科, 浙江临海 317016

详细信息

通讯作者: 裘加人,E-mail:qiujr130@163.com

中图分类号: R575

收稿日期: 2014-12-09

The relationship between CT features of primary liver cancer and the expression of VEGF in liver tissue

QIU Jia-ren^,

- Department of Radiology, the Second People's Hospital of Linhai, Zhejiang 317016, China

More Information

Corresponding author: QIU Jia-ren, E-mail: qiujr130@163.com

Received Date: 09 December 2014

摘要

摘要: [目的]探讨原发性肝癌患者CT征象与表皮生长因子(VEGF)表达之间的关系,为临床治疗肝癌提供参考。[方法]36例原发性肝癌患者术前行CT扫描,记录CT表现特征,观察肿瘤大小及强化类型、包膜形成等情况,采用免疫组化法检测患者及22例对照组肝硬化者肝组织VEGF表达水平,并分析原发性肝癌CT征象与VEGF表达之间的关系。[结果]原发性肝癌患者VEGF表达水平显著高于对照组(P＜0.001),肝癌CT征象中肿瘤大小与VEGF表达水平无关,包膜是否完整、强化类型与侵袭性与VEGF表达有关(P＜0.05)。[结论]VEGF异常表达与肝癌发生发展有关,肝癌CT征象中包膜是否完整、侵袭性及强化类型与肝癌组织中VEGF表达升高相关,肝癌CT征象可在一定程度上反映VEGF表达。
- 原发性肝癌 /
- VEGF /
- CT征象
Abstract: [Objective] To investigate the relationship between CT signs and the expression of VEGF in patients with primary liver cancer so as to provide a reference for clinical treatment of liver cancer.[Methods] Thirty-six cases of primary liver cancer patients underwent preoperative CT scans. CT features were recorded,and the size of tumor, type of strengthening, capsule formation,etc. were observed. The expression of VEGF was detected using the ELISA method,and the relationship between CT signs of hepatocellular carcinoma and VEGF expression was analyzed.[Results] VEGF expression was significantly higher in patients with primary liver cancer than those with hepatocellular carcinoma(P＜0.001). CT signs of tumor size was not related to VEGF expression, but the integrity of envelope, type of strengthening,and invasion were related to VEGF expression levels(P＜0.05).[Conclusion] Abnormal expression of VEGF is related to the occurrence of liver cancer. The integrity of envelope,invasion and strengthening type of CT signs are associated with increased expression of VEGF. CT findings of liver cancer may reflect the expression of VEGF to some extent.
- Primary liver cancer /
- VEGF /
- CT features

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