Observation on the effect of Wuwei Tongbian tea combined with compound polyethylene glycol electrolyte powder in bowel preparation prior to colonoscopy in patients with functional constipation
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摘要: 目的 探究五味通便茶联合复方聚乙二醇电解质散(compound polyethylene glycol electrolyte powder，PEG)对功能性便秘肠道准备的效果。方法 选取昆山市中西医结合医院2022年1月—2024年1月行结肠镜检查的480例功能性便秘患者为研究对象。对照组(n=233例)将3盒PEG加入3 000 mL温水中，分次口服。观察组(n=247例)在对照组基础上提前1 d取五味通便茶泡饮。记录两组患者的肠道清洁度、气泡情况、用药方案接受度、息肉检出率及安全性。结果 观察组患者肠道清洁度Boston肠道准备量表评分优于对照组(P < 0.01)，恶心呕吐、腹胀的发生率低于对照组(P < 0.01)，用药方案接受度明显高于对照组(P < 0.01)。结论 五味通便茶联合PEG在功能性便秘患者肠道准备中的效果优于单纯使用PEG，肠道清洁度更高，不良反应少，患者更易接受，具有一定的临床推广价值。
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关键词:
- 结肠镜检查 /
- 肠道准备 /
- 功能性便秘 /
- 五味通便茶 /
- 复方聚乙二醇电解质散
Abstract: Objective To explore the effect of Wuwei Tongbian tea combined with compound polyethylene glycol electrolyte powder(PEG) on bowel preparation before colonoscopy in patients with functional constipation.Methods A total of 480 patients with constipation who underwent colonoscopy in Kunshan Integrated Traditional and Western Medicine Hospital from January 2022 to January 2024 were selected as the research objects. The control group(233 cases) was given three packages PEG added to 3 000 mL warm water, orally taken in batches. The observation group(247 cases) took Wuwei Tongbian tea one day in advance on the basis of the control group. The intestinal cleanliness, bubble condition, acceptance of medication regimen, polyp detection rate and safety evaluation of the two groups were recorded.Results The Boston bowel preparation scale score of intestinal cleanliness in the observation group patients was significantly better than the control group(P < 0.01), and the incidence of nausea, vomiting, and abdominal distension was lower than the control group(P < 0.01). Furthermore, the acceptance of the treatment plan of the observation group patients was higher than that of the control group(P < 0.01).Conclusion The effect of Wuwei Tongbian tea combined with PEG in bowel preparation of patients with functional constipation is better than that of PEG alone. The intestinal cleanliness is better, the side effects are less, and the patients are more acceptable. It has certain clinical promotion value. -
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表 1 两组患者肠道清洁评分、气泡评分及方案接受度的比较
分，X±S 观察指标 对照组(n=233) 观察组(n=247) t P BBPS评分 6.936±0.731 8.328±0.813 -19.754 0.003 左半结肠 1.953±0.362 2.842±0.376 -26.371 0.002 中段结肠 2.232±0.433 2.765±0.434 -13.471 0.003 右半结肠 2.751±0.443 2.721±0.450 0.746 0.456 气泡评分 16.618±1.431 16.725±1.519 -0.791 0.429 直肠 2.712±0.490 2.769±0.422 -1.356 0.176 乙状结肠 2.082±0.628 2.134±0.586 -0.939 0.348 降结肠 2.305±0.735 2.364±0.719 -0.899 0.369 横结肠 2.927±0.261 2.879±0.351 1.724 0.085 升结肠 1.966±0.694 2.020±0.683 -0.868 0.386 回盲部 2.639±0.490 2.563±0.497 1.703 0.089 回肠末端 1.987±0.173 1.996±0.110 -0.670 0.503 方案接受度 1.305±0.471 1.874±0.388 -14.421 0.006 
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表 2 两组患者的结肠息肉检出情况比较
例 组别 例数 息肉直径/cm 检出率/% < 0.5 0.5~1.0 >1.0 对照组 233 24 37 15 32.618 观察组 247 22 36 12 28.340 χ2 1.224 1.037 P 0.747 0.309
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表 3 两组患者肠道准备用药后安全性评价比较
分，X±S 组别 例数 恶心呕吐 腹胀 腹痛 头晕头痛 口干 乏力 对照组 233 1.845±0.374 1.691±0.481 0.734±0.443 0.781±0.414 0.702±0.375 0.843±0.536 观察组 247 0.931±0.382 0.972±0.427 0.700±0.485 0.709±0.464 0.721±0.483 0.852±0.649 t 26.508 17.286 0.791 1.810 0.526 0.563 P 0.003 0.007 0.429 0.071 0.468 0.453
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表 4 两组患者肠道准备用药后电解质情况比较
mmol/L，X±S 组别 例数 血钠 血钾 血镁 血氯 对照组 198 136.34±0.25 4.68±0.37 0.79±0.58 106.35±0.59 观察组 215 141.47±0.14 4.56±0.52 0.82±0.38 104.28±0.65 t 23.425 3.576 0.368 34.785 P 0.258 0.127 0.096 0.068
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