Clinical research progress on traditional Chinese medicine diagnosis and treatment of Crohn's disease
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摘要: 克罗恩病(CD)是一种病因未明、可累及全消化道的特发性炎症性疾病，本病病程迁延反复，以腹痛、腹泻、瘘管形成等为主要症状。目前西医治疗存在治疗达标率低、复发率较高、不良反应较多等不足。中医诊治CD尚处于起步阶段，研究发现中医药在缓解症状、抑制炎症反应、改善凝血功能、促进黏膜愈合、提高生物制剂临床应答率、减少复发率及治疗肛周并发症等方面具有作用。本文对近10年来中医对CD的病因病机的认识、中医辨证分型和中医治疗的文献进行综述。Abstract: Crohn's disease (CD) is an idiopathic inflammatory disease of undetermined etiology that can involve the entire digestive tract. It presents recurrent or persisting abdominal pain, diarrhea, or fistula as the main symptoms. There are many deficiencies such as lower treat-to-target rate, higher relapse rate, and higher intolerance rate in Western medicine treatment on CD. Traditional Chinese medicine (TCM) treatment on CD is still in its infancy. It has been reported that TCM could be effective in relieving symptoms, inhibiting inflammation, improving coagulation function, promoting mucosal healing, increasing the clinical response rate of biologics, reducing recurrence rate, and treating perianal complications. The literature in recent 10 years related to TCM etiology and pathogenesis, TCM syndrome differentiation and TCM treatment on CD has been reviewed.
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