饮食因素对功能性消化不良的影响

李岩; 姚鑫洁

doi:10.3969/j.issn.1671-038X.2023.10.03

饮食因素对功能性消化不良的影响

李岩^1, ,,
姚鑫洁¹

- 中国医科大学附属盛京医院第一消化内科(沈阳，110004)

详细信息

通讯作者: 李岩，E-mail：yanli0227@126.com

中图分类号: R57

收稿日期: 2023-08-15

刊出日期: 2023-10-15

Effect of dietary factors on functional dyspepsia

LI Yan^1, ,,
YAO Xinjie¹

- First Department of Gastroenterology, Shengjing Hospital Affiliated to China Medical University, Shenyang, 110004, China

More Information

Corresponding author: LI Yan, E-mail: yanli0227@126.com

Received Date: 15 August 2023

Publish Date: 15 October 2023

摘要

摘要: 功能性消化不良(FD)是一种常见的消化系统疾病，严重影响患者的生活质量。该研究旨在探讨饮食因素对FD的影响。研究发现，饮食在FD的症状诱发和病情进展中发挥一定作用。高脂饮食与FD的发病有关，高脂饮食可能通过影响消化道激素的分泌诱导或加重患者症状。谷蛋白或麸质饮食与FD的症状诱导相关，无谷蛋白饮食能够改善患者的消化不良症状。碳水化合物和FODMAPs饮食也在一定程度上诱发FD症状的发生，而水果和蔬菜的摄入可能对缓解FD症状有帮助。饮食习惯和认知因素也会影响FD的症状发作。目前虽有一些研究支持饮食与FD之间的关系，但仍缺乏高质量的研究来指导FD患者的饮食管理方案。本研究主要综述了饮食因素在FD症状诱发及病情进展中的作用，未来仍需更多的临床研究来验证这些发现，为患者提供更准确的饮食建议。
- 功能性消化不良 /
- 饮食因素
Abstract: Functional dyspepsia(FD) is a common digestive disorder that significantly impacts patients' quality of life.This study investigates the impact of dietary factors on FD.The research reveals that diet plays a role in triggering and developing FD symptoms.High-fat diets are associated with FD onset.Potentially by affecting the secretion of digestive hormones and exacerbating symptoms.Consumption of gluten or cereal protein is linked to FD symptoms, with gluten-free diets showing potential symptom improvement. Carbohydrates and FODMAPs diets also play a role in triggering and developing FD symptoms, while fruits and vegetables might alleviate FD symptoms. Dietary habits and cognitive factors also influence symptom occurrence. While some studies support the diet-FD relationship, high-quality research guiding dietary management for FD patients remains scarce.This study primarily provides an overview of the role of dietary factors in triggering and progressing functional gastrointestinal symptoms. Further investigations are necessary to better understand dietary factors in FD and provide more precise dietary recommendations for patients.
- functional dyspepsia /
- dietary factors

HTML全文

参考文献(44)

[1]	Enck P, Azpiroz F, Boeckxstaens G, et al. Functional dyspepsia[J]. Nat Rev Dis Primers, 2017, 3: 17081. doi: 10.1038/nrdp.2017.81
[2]	Drossman DA, Hasler WL. Rome Ⅳ-Functional GI Disorders: Disorders of Gut-Brain Interaction[J]. Gastroenterology, 2016, 150(6): 1257-1261. doi: 10.1053/j.gastro.2016.03.035
[3]	中国中国中西医结合学会消化系统疾病专业委员会. 功能性消化不良的中西医结合诊疗共识意见(2010)[J]. 中国中西医结合杂志, 2011, 31(11): 1545-1549. https://www.cnki.com.cn/Article/CJFDTOTAL-ZXPW201712001.htm
[4]	Bisschops R, Karamanolis G, Arts J, et al. Relationship between symptoms and ingestion of a meal in functional dyspepsia[J]. Gut, 2008, 57(11): 1495-1503. doi: 10.1136/gut.2007.137125
[5]	Pilichiewicz AN, Horowitz M, Holtmann GJ, et al. Relationship between symptoms and dietary patterns in patients with functional dyspepsia[J]. Clin Gastroenterol Hepatol, 2009, 7(3): 317-322. doi: 10.1016/j.cgh.2008.09.007
[6]	Xu JH, Lai Y, Zhuang LP, et al. Certain Dietary Habits Contribute to the Functional Dyspepsia in South China Rural Area[J]. Med Sci Monit, 2017, 23: 3942-3951. doi: 10.12659/MSM.902705
[7]	Göktaş Z, Köklü S, Dikmen D, et al. Nutritional habits in functional dyspepsia and its subgroups: a comparative study[J]. Scand J Gastroenterol, 2016, 51(8): 903-907. doi: 10.3109/00365521.2016.1164238
[8]	Agah S, Aminianfar A, Hassanzadeh Keshteli A, et al. Association between Dietary Macronutrient Intake and Symptoms in Uninvestigated Dyspepsia: Evidence from a Population-Based, Cross-Sectional Study[J]. Nutrients, 2022, 14(13): 2577. doi: 10.3390/nu14132577
[9]	Duncanson KR, Talley NJ, Walker MM, et al. Food and functional dyspepsia: a systematic review[J]. J Hum Nutr Diet, 2018, 31(3): 390-407. doi: 10.1111/jhn.12506
[10]	Feinle-Bisset C, Meier B, Fried M, et al. Role of cognitive factors in symptom induction following high and low fat meals in patients with functional dyspepsia[J]. Gut, 2003, 52(10): 1414-1418. doi: 10.1136/gut.52.10.1414
[11]	Feinle-Bisset C, Azpiroz F. Dietary and lifestyle factors in functional dyspepsia[J]. Nat Rev Gastroenterol Hepatol, 2013, 10(3): 150-157. doi: 10.1038/nrgastro.2012.246
[12]	Pilichiewicz AN, Feltrin KL, Horowitz M, et al. Functional dyspepsia is associated with a greater symptomatic response to fat but not carbohydrate, increased fasting and postprandial CCK, and diminished PYY[J]. Am J Gastroenterol, 2008, 103(10): 2613-2623. doi: 10.1111/j.1572-0241.2008.02041.x
[13]	Barbera R, Feinle C, Read NW. Abnormal sensitivity to duodenal lipid infusion in patients with functional dyspepsia[J]. Eur J Gastroenterol Hepatol, 1995, 7(11): 1051-1057. doi: 10.1097/00042737-199511000-00007
[14]	Li H, Page AJ. Altered Vagal Signaling and Its Pathophysiological Roles in Functional Dyspepsia[J]. Front Neurosci, 2022, 16: 858612. doi: 10.3389/fnins.2022.858612
[15]	Hajishafiee M, Bitarafan V, Feinle-Bisset C. Gastrointestinal Sensing of Meal-Related Signals in Humans, and Dysregulations in Eating-Related Disorders[J]. Nutrients, 2019, 11(6): 1298. doi: 10.3390/nu11061298
[16]	Wachsmuth HR, Weninger SN, Duca FA. Role of the gut-brain axis in energy and glucose metabolism[J]. Exp Mol Med, 2022, 54(4): 377-392. doi: 10.1038/s12276-021-00677-w
[17]	Pilichiewicz A, Feltrin KL, Horowitz M, et al. T1329 Oral Carbohydrate and Fat Differentially Modulate Symptoms, Gut Hormones and Antral Area in Functional Dyspepsia[J]. Gastroenterology, 2008;134(4): A-532.
[18]	Elli L, Tomba C, Branchi F, et al. Evidence for the Presence of Non-Celiac Gluten Sensitivity in Patients with Functional Gastrointestinal Symptoms: Results from a Multicenter Randomized Double-Blind Placebo-Controlled Gluten Challenge[J]. Nutrients, 2016, 8(2): 84. doi: 10.3390/nu8020084
[19]	Santolaria S, Alcedo J, Cuartero B, et al. Spectrum of gluten-sensitive enteropathy in patients with dysmotility-like dyspepsia[J]. Gastroenterol Hepatol, 2013, 36(1): 11-20. doi: 10.1016/j.gastrohep.2012.07.011
[20]	Talley NJ, Ford AC. Functional Dyspepsia[J]. N Engl J Med, 2015, 373(19): 1853-1563. doi: 10.1056/NEJMra1501505
[21]	Shahbazkhani B, Fanaeian MM, Farahvash MJ, et al. Prevalence of Non-Celiac Gluten Sensitivity in Patients with Refractory Functional Dyspepsia: a Randomized Double-blind Placebo Controlled Trial[J]. Sci Rep, 2020, 10(1): 2401. doi: 10.1038/s41598-020-59532-z
[22]	Du L, Shen J, Kim JJ, et al. Impact of gluten consumption in patients with functional dyspepsia: A case-control study[J]. J Gastroenterol Hepatol, 2018, 33(1): 128-133. doi: 10.1111/jgh.13813
[23]	Zanini B, Lanzarotto F, Villanacci V, et al. Clinical expression of lymphocytic duodenosis in "mild enteropathy" celiac disease and in functional gastrointestinal syndromes[J]. Scand J Gastroenterol, 2014, 49(7): 794-800. doi: 10.3109/00365521.2014.919017
[24]	Vanheel H, Vanuytsel T, Farré R, et al. Authors' response: Impaired duodenal mucosal integrity and low-grade inflammation in functional dyspepsia[J]. Gut, 2015, 64(2): 357-358. doi: 10.1136/gutjnl-2014-307325
[25]	Mullan A, Kavanagh P, O'Mahony P, et al. Food and nutrient intakes and eating patterns in functional and organic dyspepsia[J]. Eur J Clin Nutr, 1994, 48(2): 97-105.
[26]	Carvalho RV, Lorena SL, Almeida JR, et al. Food intolerance, diet composition, and eating patterns in functional dyspepsia patients[J]. Dig Dis Sci, 2010, 55(1): 60-65. doi: 10.1007/s10620-008-0698-8
[27]	Patcharatrakul T, Linlawan S, Plaidum S, et al. The Effect of Rice vs. Wheat Ingestion on Postprandial Gastroesophageal Reflux(GER)Symptoms in Patients with Overlapping GERD-Irritable Bowel Syndrome(IBS)[J]. Foods, 2021, 11(1): 26. doi: 10.3390/foods11010026
[28]	Pi X, Hua H, Wu Q, et al. Effects of Different Feeding Methodson the Structure, Metabolism, and Gas Production of Infant and Toddler Intestinal Flora and Their Mechanisms[J]. Nutrients, 2022, 14(8): 1568. doi: 10.3390/nu14081568
[29]	Gibson PR, Shepherd SJ. Evidence-based dietary management of functional gastrointestinal symptoms: The FODMAP approach[J]. J Gastroenterol Hepatol, 2010, 25(2): 252-258. doi: 10.1111/j.1440-1746.2009.06149.x
[30]	De Giorgio R, Volta U, Gibson PR. Sensitivity to wheat, gluten and FODMAPs in IBS: facts or fiction?[J]. Gut, 2016, 65(1): 169-178. doi: 10.1136/gutjnl-2015-309757
[31]	de Roest RH, Dobbs BR, Chapman BA, et al. The low FODMAP diet improves gastrointestinal symptoms in patients with irritable bowel syndrome: a prospective study[J]. Int J Clin Pract, 2013, 67(9): 895-903. doi: 10.1111/ijcp.12128
[32]	Choi YJ, Kim N, Yoon H, et al. Overlap between irritable bowel syndrome and functional dyspepsia including subtype analyses[J]. J Gastroenterol Hepatol, 2017, 32(9): 1553-1561. doi: 10.1111/jgh.13756
[33]	Biesiekierski JR, Peters SL, Newnham ED, et al. No effects of gluten in patients with self-reported non-celiac gluten sensitivity after dietary reduction of fermentable, poorly absorbed, short-chain carbohydrates[J]. Gastroenterology, 2013, 145(2): 320-328. e1-3. doi: 10.1053/j.gastro.2013.04.051
[34]	Oshima T, Fukui H, Watari J, et al. Childhood abuse history is associated with the development of dyspepsia: a population-based survey in Japan[J]. J Gastroenterol, 2015, 50(7): 744-750. doi: 10.1007/s00535-014-1014-3
[35]	Halder SL, Locke GR 3rd, Schleck CD, et al. Influence of alcohol consumption on IBS and dyspepsia[J]. Neurogastroenterol Motil, 2006, 18(11): 1001-1008. doi: 10.1111/j.1365-2982.2006.00815.x
[36]	Duboc H, Latrache S, Nebunu N, et al. The Role of Diet in Functional Dyspepsia Management[J]. Front Psychiatry, 2020, 11: 23.
[37]	Huaman JW, Mego M, Bendezú A, et al. Correction of Dyssynergic Defecation, but Not Fiber Supplementation, Reduces Symptoms of Functional Dyspepsia in Patients With Constipation in a Randomized Trial[J]. Clin Gastroenterol Hepatol, 2020, 18(11): 2463-2470. e1. doi: 10.1016/j.cgh.2019.11.048
[38]	Okawa Y, Fukudo S, Sanada H. Specific foods can reduce symptoms of irritable bowel syndrome and functional constipation: a review[J]. Biopsychosoc Med, 2019, 13: 10. doi: 10.1186/s13030-019-0152-5
[39]	Manichanh C, Estrella S, Hernandez C, et al. Mo1170 Flatulence: Is it What it Seems? Clinical, Physiological and Microbiological Features[J]. Gastroenterology. 2012;142(5): S-611-S-612.
[40]	Lansky S, Betancourt JM, Zhang J, et al. A pentameric TRPV3 channel with a dilated pore[J]. Nature, 2023, 621(7977): 206-214. doi: 10.1038/s41586-023-06470-1
[41]	Hammer J, Führer M, Pipal L, et al. Hypersensitivity for capsaicin in patients with functional dyspepsia[J]. Neurogastroenterol Motil, 2008, 20(2): 125-133.
[42]	Tabibian SR, Hajhashemy Z, Shaabani P, et al. The relationship between fruit and vegetable intake with functional dyspepsia in adults[J]. Neurogastroenterol Motil, 2021, 33(9): e14129. doi: 10.1111/nmo.14129
[43]	Filipović BF, Randjelovic T, Kovacevic N, et al. Laboratory parameters and nutritional status in patients with functional dyspepsia[J]. Eur J Intern Med, 2011, 22(3): 300-304. doi: 10.1016/j.ejim.2011.01.012
[44]	Sinn DH, Shin DH, Lim SW, et al. The speed of eating and functional dyspepsia in young women[J]. Gut Liver, 2010, 4(2): 173-178. doi: 10.5009/gnl.2010.4.2.173