Discussion on the research idea of the syndromes and pathological mechanism of post-infectious irritable bowel syndrome
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摘要: 感染后肠易激综合征是肠易激综合征的一种类型，即以前无IBS症状的人群在感染性胃肠炎发作后随即发生的肠易激综合征。肠道免疫活化、持续低度炎症和内脏高敏感是感染后肠易激综合征主要的病理特征；而在肝郁脾虚的基础上存在邪气未尽、伏藏于内的正邪交争状态是其中医病机特点，其中湿邪是导致其反复发作，难以速去的关键。该文从肠道免疫活化介导内脏高敏感的角度探讨其核心病机肝郁脾虚夹湿证病理机制的研究思路，以期为后续的进一步深入研究提供参考。Abstract: Post-infectious irritable bowel syndrome is a type of irritable bowel syndrome that occurs immediately after the onset of infectious gastroenteritis in people who previously had no symptoms of irritable bowel syndrome. Intestinal immune activation, persistent low-grade inflammation and visceral hypersensitivity are the main pathological features of post-infectious irritable bowel syndrome. On the basis of liver stagnation and spleen deficiency, there is a state of conflict between healthy Qi and pathogenic evils, which is the characteristic of Traditional Chinese Medicine pathogenesis. Meanwhile, damp evil is the key to its repeated attacks and difficult to go away quickly. Therefore, from the perspective of intestinal immune activation mediating visceral hypersensitivity, this paper discussed the research ideas on the pathological mechanism of the syndrome of dampness with depression of liver and deficiency of spleen, which is the core pathogenesis, in order to provide reference for further research.
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