Cajal间质细胞在消化道动力障碍性疾病中的研究进展

刘琰; 唐艳萍

doi:10.3969/j.issn.1671-038X.2022.08.13

Cajal间质细胞在消化道动力障碍性疾病中的研究进展

刘琰¹,
唐艳萍^2,Δ, ,

- 1.
  天津中医药大学研究生院(天津，301617)
- 2.
  天津市南开医院消化内科
基金项目:
国家自然科学基金(No: 82074213, No: 81573737)

详细信息

通讯作者: 唐艳萍，E-mail：cb1699@sina.com

^Δ审校者

中图分类号: R473.6

收稿日期: 2022-05-10

刊出日期: 2022-08-15

Research progress of interstitial cells of Cajal in gastrointestinal motility disorders

LIU Yan¹,
TANG Yanping^2,Δ, ,

- 1.
  Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China
- 2.
  Department of Gastroenterology, Tianjin Nankai Hospital

More Information

Corresponding author: TANG Yanping, E-mail: cb1699@sina.com

Received Date: 10 May 2022

Publish Date: 15 August 2022

摘要

摘要: Cajal间质细胞广泛分布于人类和哺乳动物的消化道肌层中，被称为消化道的起搏细胞，其结构和数量的改变可导致消化道动力障碍。Cajal间质细胞有重要的生理功能，有望成为消化道动力障碍性疾病治疗的新靶点。该文拟对Cajal间质细胞的基本特征及其在消化道动力障碍性疾病中作用的相关研究作一综述。
- 消化道动力障碍性疾病 /
- Cajal间质细胞
Abstract: Interstitial cells of Cajal(ICCs) are widely distributed in the muscular layer of human and mammalian digestive tract. They are called pacing cells of digestive tract. The change of their structure and quantity can lead to gastrointestinal motility disorder. Because of their important physiological functions, ICCs are expected to become a new target for the treatment of gastrointestinal motility disorders. This paper reviews the basic characteristics of ICCs and their role in gastrointestinal motility disorders.
- gastrointestinal motility disorders /
- interstitial cells of Cajal

HTML全文

参考文献(48)

[1]	Foong D, Zhou J, Zarrouk A, et al. Understanding the Biology of Human Interstitial Cells of Cajal in Gastrointestinal Motility[J]. Int J Mol Sci, 2020, 21(12): 4540. doi: 10.3390/ijms21124540
[2]	Omer E, Kedar A, Nagarajarao HS, et al. Cajal Cell Counts are Important Predictors of Outcomes in Drug Refractory Gastroparesis Patients with Neurostimulation[J]. J Clin Gastroenterol, 2019, 53(5): 366-372. doi: 10.1097/MCG.0000000000001025
[3]	Blair PJ, Rhee PL, Sanders KM, et al. The significance of interstitial cells in neurogastroenterology[J]. J Neurogastroenterol Motil, 2014, 20(3): 294-317. doi: 10.5056/jnm14060
[4]	Sanders KM, Ward SM, Koh SD. Interstitial cells: regulators of smooth muscle function[J]. Physiol Rev, 2014, 94(3): 859-907. doi: 10.1152/physrev.00037.2013
[5]	毛兰芳, 汪龙德, 杜晓娟, 等. 基于ICC自噬探讨疏肝健脾法调节功能性消化不良胃肠动力障碍的研究思路[J]. 中国中医基础医学杂志, 2021, 27(12): 1916-1919. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYJC202112021.htm
[6]	陈峭, 谢胜, 周晓玲, 等. "以俞调枢"法对胃肠动力障碍模型大鼠消化道内Cajal间质细胞超微结构表达的影响[J]. 中华中医药学刊, 2019, 37(12): 2959-2962, 3113-3114. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYHS201912034.htm
[7]	Komuro T. Comparative morphology of interstitial cells of Cajal: ultrastructural characterization[J]. Microsc Res Tech, 1999, 47(4): 267-285. doi: 10.1002/(SICI)1097-0029(19991115)47:4<267::AID-JEMT5>3.0.CO;2-O
[8]	Maes M, Cogliati B, Crespo Yanguas S, et al. Roles of connexins and pannexins in digestive homeostasis[J]. Cell Mol Life Sci, 2015, 72(15): 2809-2821. doi: 10.1007/s00018-015-1961-8
[9]	Komuro T. Structure and organization of interstitial cells of Cajal in the gastrointestinal tract[J]. J Physiol, 2006, 576(Pt3): 653-658.
[10]	Iino S, Horiguchi S, Horiguchi K, et al. Interstitial cells of Cajal in Wsh/Wsh c-kit mutant mice[J]. J Smooth Muscle Res, 2020, 56(1): 58-68
[11]	Drumm BT, Hennig GW, Battersby MJ, et al. Clustering of Ca²⁺ transients in interstitial cells of Cajal defines slow wave duration[J]. J Gen Physiol, 2017, 149(7): 703-725. doi: 10.1085/jgp.201711771
[12]	陈容, 周必英, 周泠. 白术破壁饮片对慢传输型便秘小鼠肠神经递质及ICC的影响[J]. 重庆医科大学学报, 2022, 47(1): 1-8. https://www.cnki.com.cn/Article/CJFDTOTAL-ZQYK202201001.htm
[13]	Won KJ, Sanders KM, Ward SM. Interstitial cells of Cajal mediate mechanosensitive responses in the stomach[J]. Proc Natl Acad Sci USA, 2005, 102(41): 14913-14918. doi: 10.1073/pnas.0503628102
[14]	刘琰, 唐艳萍, 刘磊, 等. 活血通降方对反流性食管炎模型大鼠食管动力、血清炎症因子及食管下括约肌SCF/c-kit信号通路的影响[J]. 中医杂志, 2022, 63(3): 269-275. https://www.cnki.com.cn/Article/CJFDTOTAL-ZZYZ202203013.htm
[15]	谢胜, 刘洪武, 黎丽群, 等. 背俞指针疗法对GERD大鼠食管下端组织的ICC内质网AMPK/mTOR自噬通路的影响[J]. 中华中医药学刊, 2021, 39(2): 259-260. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYHS202102003.htm
[16]	孙永顺, 尚盈盈, 朱生樑. 丁香降气方对反流性食管炎大鼠胃排空及Cajal间质细胞影响的实验研究[J]. 新中医, 2012, 44(10): 130-133. https://www.cnki.com.cn/Article/CJFDTOTAL-REND201210059.htm
[17]	谭金晶, 黎丽群, 侯秋科, 等. 背俞指针疗法对GERD大鼠胃起搏区Cajal间质细胞及SCF表达的影响[J]. 时珍国医国药, 2021, 32(6): 1501-1504. doi: 10.3969/j.issn.1008-0805.2021.06.65
[18]	Vaezi MF, Pandolfino JE, Yadlapati RH, et al. ACG Clinical Guidelines: Diagnosis and Management of Achalasia[J]. Am J Gastroenterol, 2020, 115(9): 1393-1411. doi: 10.14309/ajg.0000000000000731
[19]	Mittal RK, Hong SJ, Bhargava V. Longitudinal muscle dysfunction in achalasia esophagus and its relevance[J]. J Neurogastroenterol Motil, 2013, 19(2): 126-136. doi: 10.5056/jnm.2013.19.2.126
[20]	Müller M, Colcuc S, Drescher DG, et al. Murine genetic deficiency of neuronal nitric oxide synthase(nNOS(-/-))and interstitial cells of Cajal(W/W(v)): Implications for achalasia?[J]. J Gastroenterol Hepatol, 2014, 29(10): 1800-1807. doi: 10.1111/jgh.12600
[21]	Liu ZQ, Chen WF, Wang Y, et al. Mast cell infiltration associated with loss of interstitial cells of Cajal and neuronal degeneration in achalasia[J]. Neurogastroenterol Motil, 2019, 31(5): e13565. doi: 10.1111/nmo.13565
[22]	Facco M, Brun P, Baesso I, et al. T cells in the myenteric plexus of achalasia patients show a skewed TCR repertoire and react to HSV-1 antigens[J]. Am J Gastroenterol, 2008, 3(7): 1598-1609.
[23]	Wang X, Li J, Liu D, et al. Relationship between infiltrating lymphocytes in cancerous ascites and dysfunction of Cajal mesenchymal cells in the small intestine[J]. Int J Clin Exp Pathol, 2018, 11(4): 2201-2213.
[24]	Groneberg D, Zizer E, Lies B, et al. Dominant role of interstitial cells of Cajal in nitrergic relaxation of murine lower oesophageal sphincter[J]. J Physiol, 2015, 593(2): 403-414. doi: 10.1113/jphysiol.2014.273540
[25]	Ervin CM, Reasner DS, Hanlon JT, et al. Exploring the Diabetic Gastroparesis Patient Experience: Patient Exit Interviews[J]. Adv Ther, 2017, 34(12): 2680-2692. doi: 10.1007/s12325-017-0632-6
[26]	Park KS, Cho KB, Hwang IS, et al. Characterization of smooth muscle, enteric nerve, interstitial cells of Cajal, and fibroblast-like cells in the gastric musculature of patients with diabetes mellitus[J]. World J Gastroenterol, 2016, 22(46): 10131-10139. doi: 10.3748/wjg.v22.i46.10131
[27]	Bashashati M, McCallum RW. Is Interstitial Cells of Cajal-opathy Present in Gastroparesis?[J]. J Neurogastroenterol Motil, 2015, 21(4): 486-493. doi: 10.5056/jnm15075
[28]	Choi KM, Gibbons SJ, Nguyen TV, et al. Heme oxygenase-1 protects interstitial cells of Cajal from oxidative stress and reverses diabetic gastroparesis[J]. Gastroenterology, 2008, 135(6): 2055-2064. doi: 10.1053/j.gastro.2008.09.003
[29]	Choi KM, Gibbons SJ, Sha L, et al. Interleukin 10 Restores Gastric Emptying, Electrical Activity, and Interstitial Cells of Cajal Networks in Diabetic Mice[J]. Cell Mol Gastroenterol Hepatol, 2016, 2(4): 454-467. doi: 10.1016/j.jcmgh.2016.04.006
[30]	Horvath VJ, Vittal H, Lorincz A, et al. Reduced stem cell factor links smooth myopathy and loss of interstitial cells of cajal in murine diabetic gastroparesis[J]. Gastroenterology, 2006, 130(3): 759-770. doi: 10.1053/j.gastro.2005.12.027
[31]	Bernard CE, Gibbons SJ, Mann IS, et al. Association of low numbers of CD206-positive cells with loss of ICC in the gastric body of patients with diabetic gastroparesis[J]. Neurogastroenterol Motil, 2014, 26(9): 1275-1284. doi: 10.1111/nmo.12389
[32]	Kiriukhin SO, Makarova OV. Morphological changes in the colonic muscular layer and interstitial cells of Cajal in experimental acute ulcerative colitis[J]. Arkh Patol, 2016, 78(5): 27-32. doi: 10.17116/patol201678527-32
[33]	Bernardini N, Segnani C, Ippolito C, et al. Immunohistochemical analysis of myenteric ganglia and interstitial cells of Cajal in ulcerative colitis[J]. J Cell Mol Med, 2012, 16(2): 318-327. doi: 10.1111/j.1582-4934.2011.01298.x
[34]	Dai YC, Zheng L, Zhang YL, et al. Jianpi Qingchang decoction regulates intestinal motility of dextran sulfate sodium-induced colitis through reducing autophagy of interstitial cells of Cajal[J]. World J Gastroenterol, 2017, 23(26): 4724-4734. doi: 10.3748/wjg.v23.i26.4724
[35]	Porcher C, Baldo M, Henry M, et al. Deficiency of interstitial cells of Cajal in the small intestine of patients with Crohn's disease[J]. Am J Gastroenterol, 2002, 97(1): 118-125. doi: 10.1111/j.1572-0241.2002.05430.x
[36]	Milia AF, Ruffo M, Manetti M, et al. Telocytes in Crohn's disease[J]. J Cell Mol Med, 2013, 17(12): 1525-1536. doi: 10.1111/jcmm.12177
[37]	Serra J, Mascort-Roca J, Marzo-Castillejo M, et al. Clinical practice guidelines for the management of constipation in adults. Part 1: Definition, aetiology and clinical manifestations[J]. Gastroenterol Hepatol, 2017, 40(3): 132-141. doi: 10.1016/j.gastrohep.2016.02.006
[38]	Yang H, Luo H, Li YH. Effects of epidural infusion of morphine combined with small-dose naloxone on gastrointestinal interstitial cells of Cajal in rabbits[J]. Eur Rev Med Pharmacol Sci, 2019, 23(6): 2596-2601.
[39]	周正旋, 周青, 商洪涛, 等. 养阴润肠方改善慢传输型便秘模型ICC研究[J]. 中华中医药学刊, 2018, 36(9): 2188-2191. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYHS201809035.htm
[40]	吴本升, 王晓鹏, 孙明明, 等. 基于慢传输型便秘大鼠结肠ICC及AQP3变化的温阳益气方改善便秘的作用机制探讨[J]. 时珍国医国药, 2019, 30(10): 2360-2365. https://www.cnki.com.cn/Article/CJFDTOTAL-SZGY201910017.htm
[41]	Zhang YC, Chen BX, Xie XY, et al. Role of Tenascin-X in regulating TGF-β/Smad signaling pathway in pathogenesis of slow transit constipation[J]. World J Gastroenterol, 2020, 26(7): 717-724. doi: 10.3748/wjg.v26.i7.717
[42]	Shi LL, Liu MD, Chen M, et al. Involvement of interstitial cells of Cajal in experimental severe acute pancreatitis in rats[J]. World J Gastroenterol, 2013, 19(14): 2179-2186. doi: 10.3748/wjg.v19.i14.2179
[43]	Zhao Y, Li G, Sun X, et al. Changes of amount and ultrastructure of interstitial cells of Cajal in rats with severe acute pancreatitis and their importance[J]. Int J Clin Exp Med, 2015, 8(4): 5492-5498.
[44]	宋轶, 刘杰, 路晓光, 等. 大黄附子汤改善重症急性胰腺炎大鼠肠道动力障碍的机制研究[J]. 中华急诊医学杂志, 2021, 30(8): 954-959. doi: 10.3760/cma.j.issn.1671-0282.2021.08.007
[45]	Portincasa P, Wang DQ. Effect of Inhibition of Intestinal Cholesterol Absorption on the Prevention of Cholesterol Gallstone Formation[J]. Med Chem, 2017, 13(5): 421-429.
[46]	Di Ciaula A, Garruti G, Frühbeck G, et al. The Role of Diet in the Pathogenesis of Cholesterol Gallstones[J]. Curr Med Chem, 2019, 26(19): 3620-3638.
[47]	Huang ZP, Qiu H, Yu BP. Distribution changes of interstitial cells of Cajal during cholesterol gallstone formation in guinea pigs fed a high cholesterol diet[J]. Int J Clin Exp Pathol, 2018, 11(3): 1653-1659.
[48]	Feng H, Wang F, Wang C. C-Kit expression in the gallbladder of guinea pig with chronic calculous cholecystitis and the effect of Artemisia capillaris Thunb on interstitial cells of Cajal[J]. Iran J Basic Med Sci, 2016, 19(7): 720-725.