Efficacy and safety of lactulose combined with mosapride in the treatment of senile chronic functional constipation
-
摘要: 目的 分析乳果糖联合莫沙必利对老年慢性功能性便秘患者首次排便时间、排便频率及对安全性的影响。方法 选取山西省运城市中心医院2020年1月—2021年6月收治的120例老年慢性功能性便秘患者,按照随机数字表法分为观察者和对照组,每组60例。对照组使用乳果糖口服溶液治疗,观察组使用乳果糖联合莫沙必利治疗。观察并比较2组首次排便时间分布、排便频率及安全性指标。结果 观察组首次排便时间分布显著优于对照组(P< 0.05);2组治疗后排便频率均显著提高,且组间差异有统计学意义(P< 0.01);观察组首次排便性状分型显著优于对照组(P< 0.05);2组不良反应总发生率差异无统计学意义(P>0.05)。结论 乳果糖联合莫沙必利应用于老年慢性功能性便秘患者,能够显著提前首次排便时间、提高排便频率、优化首次排便性状分型,不良反应低,安全性高,值得临床推广应用。Abstract: Objective To analyze the effect of lactulose combined with mosapride on the first defecation time, defecation frequency and safety in elderly patients with chronic functional constipation.Methods A total of 120 elderly patients with chronic functional constipation admitted to our hospital from January 2020 to June 2021 were selected and divided into two groups according to random number table method, with 60 cases in each group. The control group was treated with lactulose oral solution, and the observation group was treated with lactulose combined with mosapride. The time distribution of the first defecation, the frequency of defecation and the safety data were observed and compared between the two groups.Results The distribution of the first defecation time in the observation group was significantly better than that in the control group(P< 0.05); The frequency of defecation in both groups after treatment was significantly increased, and the difference between the groups was significant(P< 0.01); The first defecation trait classification in the observation group was significantly better than that in the control group(P< 0.05); There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Lactulose combined with mosapride in elderly patients with chronic functional constipation can significantly advance the time of first defecation, increase the frequency of defecation, and optimize the classification of first defecation traits, with low adverse reactions and high safety, which is worthy of clinical application.
-
Key words:
- functional constipation /
- lactulose oral solution /
- mosapride
-
表 1 2组基本临床资料比较
例(%) 组别 例数 性别 年龄/岁 BMI/(kg/m2) 病程/年 基础合并症 男 女 高血压 高血脂症 观察组 60 41(68.33) 19(31.67) 71.66±6.95 24.55±3.86 4.82±2.34 51(85.00) 52(86.67) 对照组 60 36(60.00) 24(40.00) 72.51±7.05 25.97±4.11 5.15±2.22 56(93.33) 47(78.33) χ2/t 0.198 0.665 1.951 0.792 0.124 0.138 P 0.656 0.507 0.053 0.430 0.725 0.710 表 2 2组治疗后首次排便时间分布比较
例(%) 组别 例数 1 d 2 d 3 d 4 d及以后 观察组 60 10(16.67) 18(30.00) 21(35.00) 11(18.33) 对照组 60 2(3.33) 7(11.67) 20(33.33) 31(51.67) χ2 4.886 4.029 0.018 7.164 P 0.027 0.045 0.893 0.007 表 3 2组治疗前后排便频率比较
次/周,X±S 组别 例数 治疗前 治疗后 t P 观察组 60 1.95±0.64 7.31±2.75 14.705 < 0.001 对照组 60 2.02±0.65 5.13±1.26 16.991 < 0.001 t 0.594 5.582 P 0.554 < 0.001 表 4 2组首次排便性状分型比较
例(%) 组别 例数 1型 2型 3型 4型 5型 6型 7型 观察组 60 0 7(11.67) 9(15.00) 23(38.33) 11(18.33) 7(11.67) 3(5.00) 对照组 60 4(6.67) 18(30.00) 23(38.33) 10(16.67) 3(5.00) 2(3.33) 0 χ2 3.875 4.029 4.877 4.046 4.018 2.588 2.929 P 0.049 0.045 0.027 0.044 0.043 0.108 0.087 表 5 2组患者不良反应发生率比较
例(%) 组别 例数 恶心 呕吐 腹泻 总发生率/% 观察组 60 3(5.00) 2(3.33) 0 8.33 对照组 60 4(6.67) 2(3.33) 1(1.67) 11.67 χ2 0.303 P 0.582 -
[1] 钱敏, 刘丰兵, 李镇, 等. 乳果糖与两种益生菌制剂三联用药治疗老年慢性功能性便秘的临床观察[J]. 上海医药, 2021, 42(22): 4. https://www.cnki.com.cn/Article/CJFDTOTAL-SYIY202122010.htm
[2] Wen SY, He F, Li YH, et al. Contrast-free coronary intervention using intravascular ultrasound guidance[J]. Chin J Interv Cardio, 2021, 29(1): 55-57.
[3] Zhao N, Ma W, Geng WL, et al. Quantitative myocardial perfusion parameters in subjects without coronary artery lesions based on computed tomography dynamic myocardial perfusion imaging[J]. Nation Med J China, 2021, (39): 3195-3201.
[4] 汪灵, 龚志荣, 王培峻, 等. 神阙穴贴敷联合电针疗法对中风后便秘患者排便次数及生活质量的影响[J]. 新疆中医药, 2021, 39(1): 33-35. https://www.cnki.com.cn/Article/CJFDTOTAL-XJZY202101014.htm
[5] 徐小勤. 腹部推拿法在对长期卧床的高龄功能性便秘患者进行治疗中的应用效果[J]. 当代医药论丛, 2020, 18(24): 133-134. doi: 10.3969/j.issn.2095-7629.2020.24.091
[6] Pan H, Yao HJ, Chang WW, et al. Clinical study on Tongmi Mixture for senile patients with constipation with Qi-Yin deficiency syndrome[J]. J New Chin Med, 2021, 53(13): 79-82.
[7] 马卫涛, 田密昌, 张团结, 等. 乳果糖联合双歧杆菌四联活菌片治疗老年慢性功能性便秘临床效果分析[J]. 内科, 2021, 16(2): 4. https://www.cnki.com.cn/Article/CJFDTOTAL-NKYT202102013.htm
[8] Zhang DD, Yan XY. Clinical observation on treatment of senile constipation of spleen and kidney deficiency with Ling Mushroom Mixture[J]. World Late MedInform, 2019, 19(43): 197-198.
[9] 中国便秘联谊会, 中国医师协会肛肠分会, 中国民族医药学会肛肠分会, 中华中医药学会肛肠分会. 2017版便秘的分度与临床策略专家共识[J]. 中华胃肠外科杂志, 2018, 21(3): 345. https://www.cnki.com.cn/Article/CJFDTOTAL-DCGM202003007.htm
[10] 杨安民, 王拥军, 熊艳鸿. 老年人功能性便秘的中医论证[J]. 中国中医药现代远程教育, 2019, 17(9): 99-100.
[11] 赵小琴. 中医全科干预对老年功能性便秘治疗的影响研究[J]. 世界最新医学信息文摘, 2019, 19(75): 225.
[12] 侯晓华, 朱斯然. 老年人功能性便秘的临床特点及诊断方法筛选[J]. 中国临床保健杂志, 2019, 22(1): 7-9.
[13] 张琎, 肖勇, 印安宁, 等. 乳果糖联合聚乙二醇方案对不同风险分层人群肠道准备效果的单中心随机对照研究[J]. 中华消化内镜杂志, 2021, 38(12): 5.
[14] 霍雨佳, 杨海明, 徐天舒, 等. 通便汤联合乳果糖口服溶液治疗慢性阻塞性肺疾病便秘患者40例临床观察[J]. 中医杂志, 2017, 58(4): 5. https://www.cnki.com.cn/Article/CJFDTOTAL-ZZYZ201704011.htm
[15] 刘永康, 杨士斌. 芪蓉润肠口服液与乳果糖对肛肠术后患者排便功能的影响[J]. 中国现代医药杂志, 2019, 21(8): 65-66. https://www.cnki.com.cn/Article/CJFDTOTAL-ZHTY201908022.htm
[16] 郭雪艳, 牛建平, 廉小延, 等. 复方聚乙二醇电解质散联合莫沙必利在便秘患者行结肠镜检查前肠道准备中应用观察[J]. 陕西医学杂志, 2013(3): 370-371. https://www.cnki.com.cn/Article/CJFDTOTAL-SXYZ201303049.htm
[17] 李凡, 张帆, 李峰学, 等. 双歧杆菌三联活菌联合莫沙必利治疗高原寒区功能性便秘临床效果观察[J]. 临床军医杂志, 2021, 49(4): 371-373. https://www.cnki.com.cn/Article/CJFDTOTAL-JYGZ202104004.htm
[18] 尚秋利. 枯草杆菌二联活菌肠溶胶囊联合莫沙必利、乳果糖口服溶液治疗便秘型肠易激综合征的效果[J]. 河南医学研究, 2021, 30(6): 1069-1071. https://www.cnki.com.cn/Article/CJFDTOTAL-HNYX202106040.htm