基于NLRP3炎症小体探讨中医药防治溃疡性结肠炎的机制

张海明; 梁凤霞; 杨胜兰; 张君丽; 袁昌劲; 陈瑞

doi:10.3969/j.issn.1671-038X.2021.07.17

基于NLRP3炎症小体探讨中医药防治溃疡性结肠炎的机制

- 1. 湖北中医药大学针灸骨伤学院针灸治未病湖北省协同创新中心(武汉, 430061);
- 2. 华中科技大学同济医学院附属协和医院中西医结合科;
- 3. 华中科技大学同济医学院附属协和医院消化内科;
- 4. 华中科技大学同济医学院附属武汉中心医院中西医结合肿瘤科
基金项目:
国家自然科学基金面上项目（No：81774401，No：81774420，No：81874397，No：81900520）；武汉市中心医院院内科研基金（No：2017Y10）

详细信息

通讯作者: 梁凤霞,E-mail:315938821@qq.com

中图分类号: R574.62

收稿日期: 2021-03-19

Mechanism of Chinese herbal medicine treatment of ulcerative colitis via nucleotide-binding oligomerization domain-like receptor protein 3 inflammasome

More Information

Corresponding author: LIANG Fengxia, E-mail: 315938821@qq.com

Received Date: 19 March 2021

摘要

- 核苷酸结合寡聚化结构域样受体蛋白3 /
- 炎症小体 /
- 溃疡性结肠炎 /
- 结直肠癌 /
- 中医药 /
- 炎-癌转化
Abstract: Ulcerative colitis(UC) is an unexplained, recurrent, chronic nonspecific intestinal disease, and chronic colitis has been shown to increase the risk of colorectal cancer.Many studies have reported that nucleotide-binding oligomerization domain-like receptor protein 3(NLRP3)inflammasome is closely related to the development of UC.Therefore, NLRP3 inflammasome are likely to become a new target for the treatment of UC.Chinese herbal medicine has the characteristics of multi-target, multi-function and multi-pathway against inflammatory, cancer and immunological diseases.This review provides a further understanding of the key mechanisms of Traditional Chinese Medicine in the regulation of NLRP3 inflammasome and demonstrates new ideas and directions for treatment of UC.
- nucleotide-binding oligomerization domain-like receptor protein 3 /
- inflammasome /
- ulcerative colitis /
- colorectal cancer /
- Traditional Chinese Medicine /
- inflammation-cancer transformation

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