Effects and mechanisms of curcumin on intestinal barrier function
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Abstract: Curcumin is the main effective ingredient of Traditional Chinese herbs turmeric. It has a variety of functions, such as anti-inflammatory, anti-oxidation and anti-tumor. However, its efficacy is controversial due to its low bioavailability. In this paper, we demonstrated that curcumin could repair the intestinal barrier function through enhancing the activity of intestinal alkaline phosphatase, maintaining the homeostasis of gut flora, promoting the secretion of mucus, increasing the level of antibacterial peptides, as well as maintaining the integrity of intestinal epithelium and tight junctions. Consequently, curcumin could reduce the harmful bacteria/bacterial products into the systemic circulation, so as to inhibit the inflammatory response and show its beneficial effects.
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Key words:
- curcumin /
- intestinal barrier function /
- target /
- chronic inflammation /
- mechanism
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