Effect of injecting neostigmine in Zusanli on spontaneous defecation function in patients with acute severe cerebral infarction
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摘要: 目的:评估足三里注射新斯的明对急性重症脑梗死患者自主排便功能影响。方法:回顾性分析2018年9月~2019年8月我院血管外科监护室收治的急性重症脑梗死患者63例,对照组30例患者予开塞露、灌肠人工辅助排便措施,治疗组33例患者予足三里注射新斯的明,观察2组患者治疗前后患者肠鸣音,治疗后24 h内自主排便次数、便血、大便失禁、瞳孔缩小等指标,评估疗效。结果:治疗组治疗前患者肠鸣音(0.6±0.9)次/min,治疗后患者肠鸣音(4.3±3.2)次/min,差异有统计学意义(P<0.05);对照组治疗后24 h内自主排便次数(0.3±0.8)次,治疗组治疗后24 h内自主排便次数(2.6±3.0)次,差异有统计学意义(P<0.05);对照组治疗后肠鸣音增加(1.2±1.5)次,治疗组治疗后肠鸣音增加(3.7±3.1)次,差异有统计学意义(P<0.05);所有患者无瞳孔缩小表现。结论:足三里注射新斯的明可促进急性重症脑梗死患者胃肠道蠕动,恢复自主排便功能,且不影响病情观察。Abstract: Objective: To evaluate the effect of injecting neostigmine in Zusanli on spontaneous defecation function in patients with acute severe cerebral infarction.Methods: We retrospectively analyzed 63 patients with acute severe cerebral infarction admitted to the Vascular Surgery Intensive Care Unit of Xuanwu Hospital of Capital Medical University from September 2018 to August 2019.30 patients in the control group were given glycerine and enema to assist in defecation, and 33 patients in the treatment group were given neostigmine injection in Zusanli. Bowel sounds before and after treatment, number of spontaneous defecation within 24 hours after treatment, hematochezia, fecal incontinence, miosis were collected for the analysis to evaluate the efficacy.Results: In the treatment group, bowel sounds were(0.6±0.9) times/min before treatment and(4.3±3.2) times/min after treatment, the difference was statistically significant(P<0.05). The frequency of spontaneous defecation in the control group was(0.3±0.8) times within 24 hours after treatment, while that in the treatment group was(2.6±3.0) times within 24 hours after treatment, the difference was statistically significant(P<0.05). After treatment, the bowel sounds in the control group increased(1.2±1.5) times, while those in the treatment group increased(3.7±3.1) times, the difference was statistically significant(P<0.05). There was no pupil narrowing observed in all patients.Conclusion: Zusanli injection of neostigmine can promote gastrointestinal peristalsis in patients with acute severe cerebral infarction, restore the function of voluntary defecation, and do not affect the observation of the disease.
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Key words:
- Zusanli /
- neostigmine /
- acute severe cerebral infarction /
- acupoint injection
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