增液承气汤联合粪菌移植对慢性功能性便秘的疗效

张慧田; 马兴婷

doi:10.3969/j.issn.1671-038X.2021.01.11

增液承气汤联合粪菌移植对慢性功能性便秘的疗效

张慧田^,,
马兴婷

- 新疆维吾尔自治区中医医院脾胃病科(乌鲁木齐, 830000)
基金项目:
新疆维吾尔族自治区卫生健康青年医学科技人才专项科研项(No:WJWY201939)

详细信息

通讯作者: 张慧田,E-mail:984410481@qq.com

中图分类号: R256.3

收稿日期: 2020-07-09

Effect of Zengye Chengqi decoction and fecal bacteria transplantation on chronic functional constipation

ZHANG Huitian^,,
MA Xingting

- Department of Spleen and Stomach Diseases, Xinjiang Uygur Autonomous Region Traditional Chinese Medicine Hospital, Urumqi, 830000, China

More Information

Corresponding author: ZHANG Huitian, E-mail: 984410481@qq.com

Received Date: 09 July 2020

摘要

摘要: 目的:探讨增液承气汤联合粪菌移植对慢性功能性便秘的疗效。方法:选取2019年5月-2020年3月收治的124例慢性功能性便秘患者,按照随机数字表法分为研究组和对照组,对照组患者接受粪菌移植治疗,研究组患者在对照组基础上进行增液承气汤治疗,分析2组患者肠道菌群变化、胃肠电变化、症状改善情况以及相关积分改善情况。结果:研究组乙酰胆碱、c-kit原癌基因、血管活性肠肽、NO水平明显高于对照组(P<0.05);研究组餐前、餐后的胃肠电幅度以及频率均明显高于对照组(P<0.05);研究组Bristol粪便性状评分明显高于对照组(P<0.05),研究组便秘患者生活质量评价表评分、Wexner便秘评分得分明显低于对照组(P<0.05);研究组厌氧菌群乳杆菌、双歧杆菌水平高于对照组(P<0.05),肠杆菌、氧菌群酵母菌水平低于对照组(P<0.05);治疗期间2组患者均未出现明显不良反应。结论:对于慢性功能性便秘患者,在粪菌移植治疗的基础上联合进行增液承气汤治疗,可以有效改善肠道菌群分布,促进患者胃肠电恢复,改善临床症状,提高患者生存质量,具有较高的安全性,可以在临床中进行推广应用。
- 粪菌移植 /
- 增液承气汤 /
- 慢性功能性便秘 /
- 肠电图 /
- 生存质量
Abstract: Objective: To explore the effect of Zengye Chengqi decoction combined with fecal bacteria transplantation on chronic functional constipation.Methods: One hundred and twenty-four patients with chronic functional constipation admitted from May 2019 to March 2020 were selected and divided into 2 groups according to the random number table method. Patients in the control group received fecal bacteria transplantation, and patients in the study group were treated on the basis of the control group. Zengye Chengqi decoction was used to analyze the changes of intestinal flora, gastrointestinal electrical changes, symptom improvement and related score improvement of the two groups of patients.Results: The levels of acetylcholine, c-kit proto-oncogene, vasoactive intestinal peptide, and NO in the study group were significantly higher than those in the control group(P<0.05).The gastrointestinal electrical amplitude and frequency before and after meals in the study group were significantly higher than those in the control group(P<0.05). The scores of Bristol fecal traits in the study group were significantly higher than those of the control group(P<0.05), and the scores of the quality of life evaluation form and Wexner constipation scores of constipation patients in the study group were significantly lower than those of the control group(P<0.05).The levels of anaerobic bacteria Lactobacillus and Bifidobacterium in the study group were higher than those in the control group(P<0.05), and the levels of Enterobacter and aerobic bacteria in the study group were lower than those in the control group(P<0.05). During treatment, there were no obvious adverse reactions in both groups.Conclusion: For patients with chronic functional constipation, combined treatment with Zengye Chengqi decoction on the basis of fecal bacteria transplantation can effectively improve the distribution of intestinal flora, promote the recovery of patients' gastrointestinal electricity, improve clinical symptoms, and improve patient survival It has high quality and high safety, and can be promoted and applied in clinical practice.
- fecal bacteria transplantation /
- Zengye Chengqi decoction /
- chronic functional constipation /
- electrointestinogram /
- quality of life

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