Abstract: [Objective]To compare the efficacy and safety of BiLing Gastralgia granule and QiZhi Gastralgia Granule in gastric ulcer with the type of liver-stomach disharmony stasis.[Methods]116 patients, diagnosed as gastric ulcer of hepatic-gastric disharmony by differentiation of syndromes in Traditional Chinese Medicine, were divided into 2 groups randomly, which were 58 patients in the experimental group and 58 participants in the control group.The patients in the former group were administered with oral 5 g BiLing Gastralgia Granule, 3 times a day for 6 weeks while the participants in latter group were administered with oral 2.5 g QiZhi Gastralgia Granule without sugar 3 times a day for 6 weeks.All the patients were evaluated according to the nimodipine method before and after the treatment as well as the safety.The evaluation indexes consisted of the relief of stomachache, symptomatic improvement of acid reflux and hernia 14, 28 and 42 days after the treatment.[Results]The sympotoms, including gastralgia, acid reflux and hernia, were all ameliorated significantly and the upper abdominal pain socre decreased dramatically 14, 28 and 42 days after the treatment (P<0.01) in the patients of two groups.The treatment in experimental group was a little bit more effective than that in control group, however, without statistical difference (P>0.05).[Conclusion]BiLing Gastralgia Granule and QiZhi Gastralgia Granule were both effective significantly in curing stomach ulcer of hepatic-gastric disharmony with superior efficiency, little adverse reaction and benefits markedly.