Abstract: [Objective] To observe the clinical effect of Tiaoganlipiliyan Decoction on gastroesophageal reflux-related laryngopharyngeal reflux disease.[Methods]Using a prospective,randomized and controlled trial,62 cases of gastroesophageal reflux-related laryngopharyngeal reflux disease were included in the study.The experimental group consists of 32 patients.The control group consists of 30 patients.The experimental group takes Tiaoganlipiliyan prescription and Omeprazole Enteric-coated Tablets orally.The control group takes Omeprazole Enteric-coated Tablets orally.The course of treatment was 4 weeks.After treatment,the reflux symptom index(RSI),TCM symptom score scale and recurrence were observed.[Results]①RSI:The RSI of the two groups decreased after 2 and 4 weeks of treatment compared with those before treatment(P＜0.05).After 4 weeks of treatment,the RSI scores of the experimental group were lower than those of the control group(P＜0.05).②Main symptoms of laryngopharyngeal reflux:The main symptoms of laryngopharyngeal reflux in the experimental group were improved after 2 and 4 weeks of treatment(P＜0.05).In the control group,the continuous clearance of the throat,cough after meals or lying down,irritating cough,foreign body sensation in pharynx,heartburn or chest pain and stomachache were improved after 2 weeks of treatment(P＜0.05),and the continuous clearance of the throat,cough after meals or lying down,foreign body sensation in pharynx,heartburn or chest pain and stomachache were improved after 4 weeks of treatment(P＜0.05).After 4 weeks of treatment,the scores of sensation of foreign body in pharynx,heartburn or chest pain and stomachache between groups were statistically different(P＜0.05).③TCM symptom score:The TCM symptom score of the two groups decreased after 2 and 4 weeks of treatment(P＜0.05),and the TCM symptom score of the experimental group was lower than that of the control group after 4 weeks of treatment(P＜0.05).④The total effective rate was 90.6% in the treatment group and 66.7% in the control group.There was significant difference between the two groups(P＜0.05).5.Follow-up of recurrence:After 4 weeks of withdrawal,25 patients in the experimental group stopped taking medicine and 7 patients took medicine again.In the control group,21 patients stopped taking medicine,3 patients maintained treatment and 6 patients took medicine again.The RSI score of the experimental group was lower than that of the control group(P＜0.05),and the RSI score of the control group was higher than that of the control group(P＜0.05).[Conclusion]Compared with omeprazole alone,Tiaogan Lipi Liyan Decoction combined with omeprazole has better clinical efficacy in the treatment of gastroesophageal reflux associated laryngopharyngeal reflux disease,and can reduce the risk of recurrence.