肠道菌群失调与功能性消化不良的相关性研究

李娟娟; 王凤云; 唐旭东; 吕林

doi:10.3969/j.issn.1671-038X.2019.01.18

肠道菌群失调与功能性消化不良的相关性研究

- 1. 北京中医药大学研究生院, 北京 100029;
- 2. 中国中医科学院西苑医院脾胃病科, 北京 100091
基金项目:
国家自然科学基金资助项目（No：81673853）

详细信息

通讯作者: 唐旭东,E-mail:txdly@sina.com

中图分类号: R57

收稿日期: 2018-10-20

Corresponding author: , E-mail: txdly@sina.com

Received Date: 20 October 2018

摘要

- 肠道菌群失调 /
- 肠道菌群 /
- 功能性消化不良 /
- 机制 /
- 综述

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参考文献(42)

[1]	张声生, 赵鲁卿.功能性消化不良中医诊疗专家共识意见(2017)[J].中华中医药杂志, 2017, 32(6):2595-2598.
[2]	Mahadeva S, Ford A C.Clinical and epidemiological differences in functional dyspepsia between the East and the West[J].Neurogastroenterol Motil, 2016, 28(2):167-174.
[3]	Napthali K, Koloski N, Walker M M, et al.Women and functional dyspepsia[J].Womens Health(Lond), 2016, 12(2):241-250.
[4]	Alander M, Satokari R, Korpela R, et al.Persistence of colonization of human colonic mucosa by a probiotic strain, Lactobacillus rhamnosus GG, after oral consumption[J].Appl Environ Microbiol, 1999, 65(1):351-354.
[5]	Qin J, Li R, Raes J, et al.A human gut microbial gene catalogue established by metagenomic sequencing[J].Nature, 2010, 464(7285):59-65.
[6]	Lozupone C A, Stombaugh J I, Gordon J I, et al.Diversity, stability and resilience of the human gut microbiota[J].Nature, 2012, 489(7415):220-230.
[7]	Jandhyala S M, Talukdar R, Subramanyam C, et al.Role of the normal gut microbiota[J].World J Gastroenterol, 2015, 21(29):8787-8803.
[8]	Wang W L, Xu S Y, Ren Z G, et al.Application of metagenomics in the human gut microbiome[J].World J Gastroenterol, 2015, 21(3):803-814.
[9]	Qiu J J, Liu Z, Zhao P, et al.Gut microbial diversity analysis using Illumina sequencing for functional dyspepsia with liver depression-spleen deficiency syndrome and the interventional Xiaoyaosan in a rat model[J].World J Gastroenterol, 2017, 23(5):810-816.
[10]	Zhong L, Shanahan E R, Raj A, et al.Dyspepsia and the microbiome:time to focus on the small intestine[J].Gut, 2017, 66(6):1168-1169.
[11]	卞慧, 谢建群, 唐志鹏, 等.胃祺饮对功能性消化不良大鼠胃排空功能及双歧杆菌、乳酸杆菌的影响[J].中国中西医结合消化杂志, 2015, 23(12):851-855.
[12]	Saad R J, Chey W D.Breath testing for small intestinal bacterial overgrowth:maximizing test accuracy[J].Clin Gastroenterol Hepatol, 2014, 12(12):1964-1972, e119-e120.
[13]	Costa M B, Azeredo I J, Marciano R D, et al.Evaluation of small intestine bacterial overgrowth in patients with functional dyspepsia through H2 breath test[J].Arq Gastroenterol, 2012, 49(4):279-283.
[14]	Lombardo L, Foti M, Ruggia O, et al.Increased incidence of small intestinal bacterial overgrowth during proton pump inhibitor therapy[J].Clin Gastroenterol Hepatol, 2010, 8(6):504-508.
[15]	Shimura S, Ishimura N, Mikami H, et al.Small Intestinal Bacterial Overgrowth in Patients with Refractory Functional Gastrointestinal Disorders[J].J Neurogastroenterol Motil, 2016, 22(1):60-68.
[16]	Takahashi T.Interdigestive migrating motor complex-its mechanism and clinical importance[J].J Smooth Muscle Res, 2013, 49:99-111.
[17]	Chai N L, Dong L, Li Z F, et al.Effects of neurotrophins on gastrointestinal myoelectric activities of rats[J].World J Gastroenterol, 2003, 9(8):1874-1877.
[18]	Jebbink H J, VanBerge-Henegouwen G P, Akkermans L M, et al.Small intestinal motor abnormalities in patients with functional dyspepsia demonstrated by ambulatory manometry[J].Gut, 1996, 38(5):694-700.
[19]	Nakae H, Tsuda A, Matsuoka T, et al.Gastric microbiota in the functional dyspepsia patients treated with probiotic yogurt[J].BMJ Open Gastroenterol, 2016, 3(1):e109.
[20]	Igarashi M, Nakae H, Matsuoka T, et al.Alteration in the gastric microbiota and its restoration by probiotics in patients with functional dyspepsia[J].BMJ Open Gastroenterol, 2017, 4(1):e144.
[21]	Vanheel H, Vicario M, Vanuytsel T, et al.Impaired duodenal mucosal integrity and low-grade inflammation in functional dyspepsia[J].Gut, 2014, 63(2):262-271.
[22]	Tanaka F, Tominaga K, Fujikawa Y, et al.Concentration of Glial Cell Line-Derived Neurotrophic Factor Positively Correlates with Symptoms in Functional Dyspepsia[J].Dig Dis Sci, 2016, 61(12):3478-3485.
[23]	Chang X, Zhao L, Wang J, et al.Sini-san improves duodenal tight junction integrity in a rat model of functional dyspepsia[J].BMC Complement Altern Med, 2017, 17(1):432-432.
[24]	郭士浩, 陈善稳, 潘义生, 等.大肠杆菌Nissle 1917与肠屏障功能的研究进展[J].肠外与肠内营养, 2018, 25(3):184-187.
[25]	Lauritano E C, Valenza V, Sparano L, et al.Small intestinal bacterial overgrowth and intestinal permeability[J].Scand J Gastroenterol, 2010, 45(9):1131-1132.
[26]	Barbara G, Feinle-Bisset C, Ghoshal U C, et al.The Intestinal Microenvironment and Functional Gastrointestinal Disorders[J].Gastroenterology, 2016, 150(6):1305-1318.
[27]	黄燕妮, 王承党.小肠细菌过度生长与功能性消化不良的关系[J].胃肠病学和肝病学杂志, 2016, 25(3):241-244.
[28]	Kindt S, Tertychnyy A, de Hertogh G, et al.Intestinal immune activation in presumed post-infectious functional dyspepsia[J].Neurogastroenterol Motil, 2009, 21(8):832-856.
[29]	Du L, Shen J, Kim J J, et al.Increased Duodenal Eosinophil Degranulation in Patients with Functional Dyspepsia:A Prospective Study[J].Sci Rep, 2016, 6:34305.
[30]	Vanheel H, Vicario M, Boesmans W, et al.Activation of Eosinophils and Mast Cells in Functional Dyspepsia:an Ultrastructural Evaluation[J].Sci Rep, 2018, 8(1):5383.
[31]	Martin C R, Osadchiy V, Kalani A, et al.The Brain-Gut-Microbiome Axis[J].Cell Mol Gastroenterol Hepatol, 2018, 6(2):133-148.
[32]	O'Mahony S M, Clarke G, Borre Y E, et al.Serotonin, tryptophan metabolism and the brain-gut-microbiome axis[J].Behav Brain Res, 2015, 277:32-48.
[33]	Sudo N, Chida Y, Aiba Y, et al.Postnatal microbial colonization programs the hypothalamic-pituitary-adrenal system for stress response in mice[J].J Physiol, 2004, 558(Pt 1):263-275.
[34]	Carabotti M, Scirocco A, Maselli M A, et al.The gut-brain axis:interactions between enteric microbiota, central and enteric nervous systems[J].Ann Gastroenterol, 2015, 28(2):203-209.
[35]	Kelly J R, Borre Y, O' B C, et al.Transferring the blues:Depression-associated gut microbiota induces neurobehavioural changes in the rat[J].J Psychiatr Res, 2016, 82:109-118.
[36]	Koloski N A, Jones M, Kalantar J, et al.The brain——gut pathway in functional gastrointestinal disorders is bidirectional:a 12-year prospective population-based study[J].Gut, 2012, 61(9):1284-1290.
[37]	杜晓娟, 汪龙德, 刘俊宏, 等.功能性消化不良与脑肠轴机制研究进展[J].辽宁中医药大学学报, 2017, 19(7):116-118.
[38]	Lee I S, Wang H, Chae Y, et al.Functional neuroimaging studies in functional dyspepsia patients:a systematic review[J].Neurogastroenterol Motil, 2016, 28(6):793-805.
[39]	Liu P, Wang G, Liu Y, et al.Disrupted intrinsic connectivity of the periaqueductal gray in patients with functional dyspepsia:A resting-state fMRI study[J].Neurogastroenterol Motil, 2017, 29(8):e13060.
[40]	王玲玲, 吴金明, 黄美君.曲美布汀联合双歧杆菌三联活菌胶囊对功能性消化不良重叠IBS-D患者肠道的影响[J].中国微生态学杂志, 2018, 30(1):59-62.
[41]	Tan V P, Liu K S, Lam F Y, et al.Randomised clinical trial:rifaximin versus placebo for the treatment of functional dyspepsia[J].Aliment Pharmacol Ther, 2017, 45(6):767-776.
[42]	陈亚琳, 余丹丹, 潘研, 等.肠道菌群失调的中医药治疗[J].世界中西医结合杂志, 2018, 13(6):879-882.