Abstract: [Objective] Patients with Helicobacter pylori (Hp) positive chronic gastritis who haven't e-radicative treatment were treated by Jinghua Weikang capsule combined with bismuth-containing quadruple therapy.The eradication rate of Hp, the improvement of clinical symptoms and the drug safety were observed.Discussing the treatment of combination of the Traditional Chinese medicine and western medicine for Hp eradication rate and Hp positive chronic gastritis.[Methods] A prospective randomized controlled multicenter clinical trial was performed on patients with chronic gastritis from Hp infection who havn't eradicative treatment from four hospitals, and all patients were divided into four groups by stratified randomization.The bismuth-containing quadruple therapy group A received esomeprazole 20 mg+amoxicillin1000 mg+furazolidone 100 mg+bismuth 200 mg, twice a day for 10 days (d1-d10).The group B received Jinghua Weikang capsule 240 mg+esomeprazole 20 mg+amoxicillin 1000 mg+furazolidone 100 mg+bismuth 200 mg, twice a day for 10 days (d1-d10).The group C1 received Jinghua Weikang capsule 240 mg (d1-d14) +esomeprazole 20 mg+amoxicillin 1000 mg+furazolidone 100 mg+bismuth 200 mg (d15-d24), twice a day for 24 days.The group C2 received esomeprazole 20 mg+amoxicillin 1000 mg+furazolidone 100 mg+bismuth 200 mg (d1-d10) + Jinghua Weikang capsule 240 mg (d11-d24), twice a day for 24 days.At the end of treatment, the Hp eradication rate, the improvement of clinical symptoms and the adverse drug reaction were evaluated in the four groups.At least 28 days after the end of treatment, the result of 13 C/14 C urea breath test were used to determine whether Hp was eradicated.[Results] A total of 471 patients included in this study, including 211 male and 260 female, whose average age was (45.7±12.1) years.Groups A, B, C1, and C2 were enrolled in 124, 114, 114, and 119 patients, respectively.The ITT analysis results of four groups of H.pylori eradication rates were 82.3% (102/124), 86.0% (98/114), 78.9% (90/114), 79.8% (95/119), respectively, but there was no statistical difference between the groups (P=0.518);The results of Per-protocol (PP) analysis were 87.9% (102/116), 90.7% (98/108), 86.5% (90/104), 85.6% (95/111), respectively.The Hp eradication rate of group B was higher than that of other treatment groups, but there is no statistical difference between the groups (P=0.677).The symptoms of all groups were significantly improved after H.pylori eradication (P<0.01), and the improvement of group B was significantly better than of group A (P=0.007).There were 32 patients with adverse drug reactions.The adverse reactions rates of the four groups were 8.1%, 6.1%, 5.3%and 7.6%, respectively, but there is no statistical difference between the groups (P=0.819).[Conclusion] The eradication rate of Jinghua Weikang capsule combined with bismuth-containing quadruple therapy coadministration is higher, and the symptoms improved significantly better than the tincture quadruple.The combination of traditional Chinese medicine and western medicine has some advantages in treating helicobacter pylori positive chronic gastritis, which deserves further study.