Abstract: [Objective]:To observe the clinical effect of Zhigancao decoction combining Zhuling decoction in the treatment of ascites due to cirrhosis of hepatitis B.[Methods] 30 patients with liver cirrhosis and ascites with TCM syndrome of insufficiency of essence and blood, deficiency of spleen qi and blood stasis, and internal stasis of dampness and water were randomly divided into 2 groups.The control group was treated with conventional western medicine(such as salt restriction, liver function protecting drugs, diuretics);The treatment group was given Zhigancao decoction combining Zhuling decoction on the basis of the control group.Both groups were treated daily for one month.The therapeutic effects were evaluated in terms of Child-Pugh score, serum albumin(ALB) counts, coagulation function(PT, PTA) and ascites mobilization.[Results] Both groups received better Child-Pugh scores after the treatment(P<0.05), and the result in the treatment group was better than that in the control group(P<0.01).The treatment group received a better ALB counts after the treatment(P<0.05), while there was no significant differences shown before and after the treatment in the control group(P>0.05).In the aspect of mobilization of ascites, both groups received better results after the treatment(P<0.05), and the result in the treatment group was better than that in the control group(P<0.01).[Conclusion] Zhigancao decoction combining Zhuling decoction can obviously improve the efficacy of Child-Pugh and blood coagulation, especially enhance the ALB and mobilize the ascites in the patients of ascites due to cirrhosis of hepatitis B by the method of nourishing the Liver and Kidneys, invigorating the Spleen, replenishing qi and activating blood, and the effect is remarkable.