The clinical influence of enteral nutrition combined with glutamine on postoperative nutritional status and liver function after subtotal gastrectomy
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摘要: [目的]探讨肠内营养联合谷氨酰胺应用在胃大部切除手术对患者营养状态和肝脏功能的影响及临床应用价值。[方法]将我院行胃大部切除手术患者148例采用随机数字法分为观察组和对照组,每组各74例,对照组给予肠内营养支持,观察组联合谷氨酰胺支持,记录2组治疗情况。[结果]观察组治疗后血清白蛋白(36.97±6.72)g/L,血清前白蛋白(198.68±14.82)mg/L;对照组治疗后血清白蛋白(33.18±3.41)g/L,血清前白蛋白(170.32±9.7)mg/L,组间对比差异有统计学意义(P＜0.05)。观察组治疗后总胆红素(9.23±1.46)μmol/L,丙氨酸氨基转移酶(21.89±2.69)U/L,门冬氨酸氨基转移酶(23.45±2.49)U/L;对照组治疗后总胆红素(12.48±3.42)μmol/L,丙氨酸氨基转移酶(32.73±5.82)U/L,门冬氨酸氨基转移酶(34.18±6.18)U/L,组间对比差异有统计学意义(P＜0.05)。观察组术后并发症发生率为5.41%,对照组术后并发症发生率为14.86%,组间对比差异有统计学意义(P＜0.05)。[结论]肠内营养联合谷氨酰胺应用在胃大部切除手术患者中可以提升患者营养状态,减轻对肝脏功能的损伤,降低术后并发症发生,值得在临床上推广应用。Abstract: [Objective]Discusses the application of enteral nutrition combined glutamine in most stomach surgery for patients nutrition status and the influence of liver function and clinical application value.[Methods]148 patients were randomly divided into observation group and control group,each group of 74 cases,the control group were given enteral nutrition support while observation group combined with glutamine support and recorded two groups' treatment.[Results]After treatment,serum albumin(36.97±6.72)g/L and serum prealbumin(198.68±14.82)mg/L were observed in the observation group while Serum albumin(33.18±3.41)g/170.32±9.7)mg/L were observed in the treatment group,the difference between the two groups was statistically significant(P＜0.05).total bilirubin(9.23±1.46)mu mol/L,alanine aminotransferase(21.89±2.69)U/L,nmda amino transferase(23.45±2.49)U/L were observed in the observation group while the total bilirubin(12.48±3.42)mu mol/L,alanine aminotransferase(32.73±5.82)U/L,nmda amino transferase(34.18±6.18)U/L were observed in the control group differences between the two groups was statistically significant(P＜0.05).The postoperative complication rate was 5.41% in the observation group and 14.86% in the control group.The difference between the two groups was significant(P＜0.05)[Conclusion]Enteral nutrition combination glutamine applied in most of the stomach surgery patients can improve patients' nutritional status,mitigate damage to liver function,reduce postoperative complications and worthy of popularization and application in clinic.
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Key words:
- enteral nutrition /
- glutamine /
- subtotal gastrectomy /
- nutritional status /
- liver function
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