基于黏膜愈合质量及基质金属蛋白酶-3、ghrelin表达探讨舒胃汤防治肝胃郁热型胃溃疡的临床研究

张琪; 梁海业; 陈世新; 李丽清

doi:10.3969/j.issn.1671-038X.2015.08.04

基于黏膜愈合质量及基质金属蛋白酶-3、ghrelin表达探讨舒胃汤防治肝胃郁热型胃溃疡的临床研究

- 桂平市中医医院脾胃病科, 广西桂平 537200
基金项目:
广西卫生厅自筹经费项目(No:Z2014554)

详细信息

作者简介:
张琪,女,本科,副主任医师,主要从事消化性溃疡中医药防治研究

通讯作者: 张琪,E-mail:398080200@qq.com

中图分类号: R256.3

收稿日期: 2015-03-02

Clinical study on Shuwei decoction through the quality of mucosa healing and the expression of matrix metalloproteinase-3and ghrelin in preventing and treating gastric ulcer of liver-stomach heat type

- Department of Gastroenterology, The TCM Hospital of Guiping City, Guiping 537200, China

More Information

Corresponding author: ZHANG Qi, E-mail: 398080200@qq.com

Received Date: 02 March 2015

摘要

摘要: [目的]通过检测胃溃疡患者治疗前、后胃镜下黏膜愈合质量、基质金属蛋白酶-3、ghrelin表达变化及中医证候积分,观察舒胃汤防治胃溃疡的可能机制。[方法]采用随机平行对照法,将40例符合诊断标准、纳入标准以及排除标准的胃溃疡患者,按1[BFZ]:[BF]1随机分为2组,即治疗组和对照组。治疗组予舒胃汤+雷贝拉唑,连续6周;对照组予雷贝拉唑,连续6周。观察胃镜评价治疗前、后黏膜愈合质量,中医证候积分评估临床疗效,荧光定量PCR法检测治疗前、后胃黏膜基质金属蛋白酶-3及ghrelin表达变化。[结果]从总体疗效分析,治疗组总有效率为95%,对照组为85%。治疗前,治疗组中医证候积分为(14.73±4.36)分,治疗后2周后中医证候积分下降,治疗后6周中医证候积分为(2.17±1.19)分,与治疗前比较,差异有统计学意义(P＜0.05)。治疗前,胃黏膜MMP-3基因表达为1.16±0.23,ghrelin基因表达为1.76±0.32;治疗后胃黏膜MMP-3基因表达为2.17±0.43,ghrelin基因表达为1.09±0.15,与治疗前比较,差异有统计学意义(P＜0.05)。[结论]舒胃汤可能通过调控基质金属蛋白酶-3、ghrelin表达,促进黏膜愈合,发挥防治胃溃疡的效用。
- 舒胃汤 /
- 胃溃疡 /
- 基质金属蛋白酶-3 /
- ghrelin
Abstract: [Objective]To assess the mechanism of Shuwei Decoction through mucosa healing quality and the expression of matrix metalloproteinases-3,ghrelin and TCM syndrome scores in the prevention and treatment of gastric ulcer.[Methods]Forty gastric ulcer patients who met the diagnostic criteria,inclusion criteria and exclusion criteria were randomly divided into intervention group and control group equally. The intervention group was given Shuwei Decoction and Rabeprazole for 6 weeks. The control group was treated with Rabeprazole for 6 weeks. The mucosa healing quality of stomach was assayed by endoscopy before and after treatment. The clinical curative effect was evaluated by TCM syndrome score. The expression of matrix metalloproteinases-3 and ghrelin in gastric mucosa were detected by PCR before and after treatment.[Results]The total effective rate of treatment group was 95%,and the control group was 85%. Before the treatment,the TCM syndrome score of intervention group was 14.73±4.36. After 2 weeks treatment,the TCM syndrome integral decreased. After 6 weeks treatment, the TCM Syndrome score was 2.17±1.19. There was significant difference between before and after treatment(P＜0.05). Before treatment,the expression of MMP-3 gene in gastric mucosa was 1.16±0.23,and the expression of ghrelin was 1.76±0.32. After treatment,the expression of MMP-3 was 2.17±0.43,and the expression of ghrelin was 1.09±0.15. There was significant difference between before and after treatment(P＜0.05).[Conclusion]Shuwei decoction can regulate the expression of matrix metalloproteinases-3 and ghrelin in order to improve mucosal healing in the prevention and treatment of gastric ulcer.
- Shuwei decoction /
- gastric ulcer /
- matrix metalloproteinase-3 /
- ghrelin

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