土槿皮乙酸的抗肿瘤作用及其分子机制

孙倩, 李岩. 土槿皮乙酸的抗肿瘤作用及其分子机制[J]. 中国中西医结合消化杂志, 2014, 22(9): 551-555. doi: 10.3969/j.issn.1671-038X.2014.09.21
引用本文: 孙倩, 李岩. 土槿皮乙酸的抗肿瘤作用及其分子机制[J]. 中国中西医结合消化杂志, 2014, 22(9): 551-555. doi: 10.3969/j.issn.1671-038X.2014.09.21

土槿皮乙酸的抗肿瘤作用及其分子机制

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    通讯作者: 李岩,E-mail:yanli2955@163.com
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  • [1]

    WONG V K, CHIU P, CHUNG S S, et al.Pseudolaric acid B, a novel microtubule-destabilizing agent that circumvents multidrug resistance phenotype and exhibits antitumor activity in vivo[J].Clin Cancer Res, 2005, 11(16):6002-6011.

    [2]

    LIU B, CHEN H, LEI Z Y, et al.Studies on anti-tumour activities of pseudolaric acid-B(PLAB) and its mechanism of action[J].J Asian Nat Prod Res, 2006, 8(3):241-252.

    [3]

    LEI X, KONG L, ZOU H, et al.Evaluation of the interaction of bioactive compounds in cortex pseudolarix and radix stephaniae by the microdialysis probe coupled with high performance liquid chromatography-mass spectrometry[J].J Chromatogr A, 2009, 1216(11):2179-2184.

    [4]

    MENG A G, JIANG L L.Pseudolaric acid B-induced apoptosis through p53-dependent pathway in human gastric carcinoma cells[J].J Asian Nat Prod Res, 2009, 11(2):142-152.

    [5]

    LI K S, GU X F, LI P, et al.Effect of pseudolaric acid B on gastric cancer cells:inhibition of proliferation and induction of apoptosis[J].World J Gastroenterol, 2005, 11(48):7555-7559.

    [6]

    徐永红, 王学清, 鞠晓华, 等.土槿皮乙酸诱导人胃癌SGC7901细胞凋亡及机制[J].中国药理学通报, 2008, 24(5):601-606.

    [7]

    JU X H, XU Y H, LI Y.Effects of pseudolaric acid B on the apoptosis, mitochondrial membrane potential and cyclooxygenase-2 Expression in hepatocellular cell line BEL-7402[J].World J Gastroenterol, 2008, 16(11):1151-1156.

    [8]

    KO J K, LEUNG W C, HO W K, et al.Herbal diterpenoids induce growth arrest and apoptosis in colon cancer cells with increased expression of the nonsteroidal anti-inflammatory drug-activated gene[J].Eur J Pharmacol, 2007, 559(1):1-13.

    [9]

    HOU L, XU B, GUO W, et al.Pseudolaric acid B inhibits inducible cyclooxygenase-2 expression via downregulation of the NF-κB pathway in HT-29 cells[J].J Cancer Res Clin Oncol, 2012,[Epub ahead of print].

    [10]

    YU J H, WANG H J, LI X R, et al.Protein tyrosine kinase, JNK, and ERK involvement in pseudolaric acid B-induced apoptosis of human breast cancer MCF-7 cells[J].Acta Pharmacol Sin, 2008, 29(9):1069-1076.

    [11]

    YU J H, CUI Q, JIANG Y Y, et al.Pseudolaric acid B induces apoptosis, senescence, and mitotic arrest in human breast cancer MCF-7[J].Acta Pharmacol Sin, 2007, 28(12):1975-1983.

    [12]

    HU Y, LI K S, MAO D W.Effect of pseudolaric acid B on telomerse activity and related genes of human ovarian cancer cells[J].J Prev Med Chin PLA, 2007, 25(1):31-33.

    [13]

    YU B, YUE D M, SHU L H, et al.Pseudolaric acid B induces caspase-dependent cell death in human ovarian cancer cells[J].Oncol Rep, 2014, 31(2):849-857.

    [14]

    GONH X, WANG M, TASHIRO S, et al.Involvement of JNK-initiated p53 accumulation and phosphorylation of p53 in pseudolaric acid B induced cell death[J].Exp Mol Med, 2006, 38(4):428-434.

    [15]

    MA G, CHONG L, LI X C, et al.Selective inhibition of human leukemia cell growth and induction of cell cycle arrest and apoptosis by pseudolaric acid B[J].J Cancer Res Clin Oncol, 2010, 136(9):1333-1340.

    [16]

    WANG J H, KAN L, SHU L H, et al.Pseudolaric acid B induces apoptosis in U937 human leukemia cells via caspase-9-mediated activation of the mitochondrial death pathway[J].Mol Med Rep, 2013, 8(3):787-793.

    [17]

    TONG Y G, ZHANG X W, GENG M Y, et al.Pseudolarix acid B, a new tubulin-binding agent, inhibits angiogenesis by interacting with a novel binding site on tubulin[J].Mol Pharmacol, 2006, 69(4):1226-1233.

    [18]

    GUAN T, YANG Y.Role of pseudolaric acid B in A549 lung cancer cell proliferation and apoptosis[J].Mol Med Rep, 2014, 9(1):144-148.

    [19]

    MAI X, XU Z W, CHEN X Y, et al.Cycle arrest of prostate carcinoma DU-145 cells induced by pseudolaric acid B[J].Zhongguo Zhong Yao Za Zhi, 2012, 37(22):3467-3471.

    [20]

    TONG J, YIN S, DONG Y, et al.Pseudolaric acid B induces caspase-dependent apoptosis and autophagic cell death in prostate cancer cells[J].Phytother Res, 2013, 27(6):885-891.

    [21]

    ZHAO D, LIN F, WU X, et al.Pseudolaric acid B induces apoptosis via proteasome-mediated Bcl-2 degradation in hormone-refractory prostate cancer DU145 cells[J].Toxicol In Vitro, 2012, 26(4):595-602.

    [22]

    QU G, SHENG Y, CHEN B, et al.Effects of pseudolaric acid B on apoptosis of bladder cancer cell 5637[J].Zhongguo Zhong Yao Za Zhi, 2011, 36(24):3535-3538.

    [23]

    MENG A G, JIANG L L.Induction of G2/M arrest by pseudolaric acid B is mediated by activation of the ATM signaling pathway[J].Acta Pharmacol Sin, 2009, 30(4):442-450.

    [24]

    KHAN M, ZHENG B, YI F, et al.Pseudolaric acid B Induces Caspase-dependent and Caspase-independent apoptosis in U87 glioblastoma Cells[J].Evid Based Complement Alternat Med, 2012, 2012:957568.

    [25]

    QI M, YAO G, FAN S, et al.Pseudolaric acid B induces mitotic catastrophe followed by apoptotic cell death in murine fibrosarcoma L929 cells[J].Eur J Pharmacol, 2012, 683(1-3):16-26.

    [26]

    QI M, FAN S, YAO G, et al.Pseudolaric acid B-induced autophagy contributes to senescence via enhancement of ROS generation and mitochondrial dysfunction in murine fibrosarcoma L929 cells[J].J Pharmacol Sci, 2013, 121(3):200-211.

    [27]

    QI M, ZHOU H, FAN S, et al.mTOR inactivation by ROS-JNK-p53 pathway plays an essential role in Psedolaric acid B induced autophagy-dependent senescence in murine fibrosarcoma L929 cells[J].Eur J Pharmacol, 2013, 715(1-3):76-88.

    [28]

    YU J H, LIU C Y, ZHENG G B, et al.Pseudolaric acid B induced cell cycle arrest, autophagy and senescence in murine fibrosarcoma l929 cell[J].Int J Med Sci, 2013, 10(6):707-718.

    [29]

    MIAO Z H, FENG J M, DING J.Newly discovered angiogenesis inhibitors and their mechanisms of action[J].Acta Pharmacol Sin, 2012, 33(9):1103-1111.

    [30]

    LIU J, GUO W, XU B, et al.Angiogenesis inhibition and cell cycle arrest induced by treatment with Pseudolarix acid B alone or combined with 5-fluorouracil[J].Acta Biochim Biophys Sin(Shanghai), 2012, 44(6):490-502.

    [31]

    WANG Y Q, JIANG Y, YANG S P, et al.Pseudolaric acid B-driven phosphorylation of c-Jun impairs its role in stabilizing HIF-1 alpha:a novel function-converter model[J].J Mol Med(Berl), 2012, 90(8):971-981.

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收稿日期:  2014-05-25

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