The clinical observation of reflux esophagitis of phlegm-heat stagnation syndrome treated by Jiawei Wendan Decoction
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摘要: [目的]观察加味温胆汤治疗反流性食管炎(reflux esophagitis,RE)的疗效。[方法]60例符合纳入标准的RE患者,随机分为2组。治疗组30例,口服加味温胆汤;对照组30例,口服奥美拉唑肠溶片和多潘立酮片;疗程均为8周。观察2组临床综合疗效,胃镜下食管黏膜的变化,评价其复发率。[结果]治疗8周后胃镜下治疗组的总有效率96.7%,高于对照组的70.0%(P<0.05)。其症状改善亦优于对照组(P<0.01),治疗组复发率为16.7%,低于对照组的72.2%(P<0.01)。[结论]加味温胆汤治疗痰热郁阻证的RE疗效优于奥美拉唑肠溶片和多潘立酮片治疗。并且安全、复发率低,可以在临床推广应用。Abstract: [Objective] To observe the therapeutic efficacy of Jiawei Weidan Decoction in treating reflux esophagitis.[Methods] Sixty cases with reflux esophagitis were randomly divided into treatment group and control group,each group containing 30 cases.Treatment group were treated with Jiawei Wendan Decoction,while control group were treated with oral omeprazole and demperidone.After a eight-week course of treatment, we observed the comprehensive curative effect and gastroscope signs under mucosa as well as the recurrence rate.[Results] The total effective rate was 96.7% in the treatment group and 70% in the control group. The difference was statistically significant (P<0.05).The improvement of symptoms in treatment group was better than that of control group (P<0.05).The recurrence rate was 16.7% in the treatment group and lower than 72.2% in the control group (P>0.01).[Conclusion] Jiawei Wendan Decoction has better effects on reflux esophagitis of phlegm-heat stagnation syndrome compared with western medieine therapy.It is safe with low recurrence rate,thus should be recommended in clinical application.
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